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6FFA

FMDV Leader protease bound to substrate ISG15

Summary for 6FFA
Entry DOI10.2210/pdb6ffa/pdb
DescriptorLbpro, Ubiquitin-like protein ISG15, GLYCEROL, ... (5 entities in total)
Functional Keywordsleader protease, deisgylase, deubiquitinase, hydrolase
Biological sourceFoot-and-mouth disease virus
More
Cellular locationProtein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B-1: Virion . Protein 3B-2: Virion . Protein 3B-3: Virion . Picornain 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03305
Cytoplasm : P05161
Total number of polymer chains2
Total formula weight28614.07
Authors
Swatek, K.N.,Pruneda, J.N.,Komander, D. (deposition date: 2018-01-05, release date: 2018-02-21, Last modification date: 2024-01-17)
Primary citationSwatek, K.N.,Aumayr, M.,Pruneda, J.N.,Visser, L.J.,Berryman, S.,Kueck, A.F.,Geurink, P.P.,Ovaa, H.,van Kuppeveld, F.J.M.,Tuthill, T.J.,Skern, T.,Komander, D.
Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.
Proc. Natl. Acad. Sci. U.S.A., 115:2371-2376, 2018
Cited by
PubMed: 29463763
DOI: 10.1073/pnas.1710617115
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

217705

数据于2024-03-27公开中

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