6FFA

FMDV Leader protease bound to substrate ISG15

6FFA の概要

• エントリーDOI: 10.2210/pdb6ffa/pdb
• 分子名称: Lbpro, Ubiquitin-like protein ISG15, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: leader protease, deisgylase, deubiquitinase, hydrolase
• 由来する生物種: Foot-and-mouth disease virus; 詳細
• 細胞内の位置: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B-1: Virion . Protein 3B-2: Virion . Protein 3B-3: Virion . Picornain 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03305; Cytoplasm : P05161
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28614.07

構造登録者

Swatek, K.N.,Pruneda, J.N.,Komander, D. (登録日: 2018-01-05, 公開日: 2018-02-21, 最終更新日: 2024-01-17)

• 主引用文献: Swatek, K.N.,Aumayr, M.,Pruneda, J.N.,Visser, L.J.,Berryman, S.,Kueck, A.F.,Geurink, P.P.,Ovaa, H.,van Kuppeveld, F.J.M.,Tuthill, T.J.,Skern, T.,Komander, D.; Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.; Proc. Natl. Acad. Sci. U.S.A., 115:2371-2376, 2018; PubMed: 29463763; DOI: 10.1073/pnas.1710617115

実験手法

X-RAY DIFFRACTION (1.5 Å)