6FD5

Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 days post crystallization (with AMP and PPi products partially generated)

Summary for 6FD5

• Entry DOI: 10.2210/pdb6fd5/pdb
• Related: 6FCH 6FCI 6FCL 6FD4 6FD6
• Descriptor: Adenine phosphoribosyltransferase, ADENOSINE MONOPHOSPHATE, PYROPHOSPHATE, ... (7 entities in total)
• Functional Keywords: rossman fold, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 40404.07

Authors

Nioche, P.,Huyet, J.,Ozeir, M. (deposition date: 2017-12-21, release date: 2018-08-15, Last modification date: 2024-01-17)

• Primary citation: Huyet, J.,Ozeir, M.,Burgevin, M.C.,Pinson, B.,Chesney, F.,Remy, J.M.,Siddiqi, A.R.,Lupoli, R.,Pinon, G.,Saint-Marc, C.,Gibert, J.F.,Morales, R.,Ceballos-Picot, I.,Barouki, R.,Daignan-Fornier, B.,Olivier-Bandini, A.,Auge, F.,Nioche, P.; Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase.; Cell Chem Biol, 25:666-676.e4, 2018; PubMed: 29576532; DOI: 10.1016/j.chembiol.2018.02.011

Experimental method