6FD5
Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 days post crystallization (with AMP and PPi products partially generated)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0002055 | molecular_function | adenine binding |
A | 0003999 | molecular_function | adenine phosphoribosyltransferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0006168 | biological_process | adenine salvage |
A | 0007625 | biological_process | grooming behavior |
A | 0016208 | molecular_function | AMP binding |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0032263 | biological_process | GMP salvage |
A | 0032264 | biological_process | IMP salvage |
A | 0034774 | cellular_component | secretory granule lumen |
A | 0044209 | biological_process | AMP salvage |
A | 0046083 | biological_process | adenine metabolic process |
A | 0070062 | cellular_component | extracellular exosome |
B | 0002055 | molecular_function | adenine binding |
B | 0003999 | molecular_function | adenine phosphoribosyltransferase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006166 | biological_process | purine ribonucleoside salvage |
B | 0006168 | biological_process | adenine salvage |
B | 0007625 | biological_process | grooming behavior |
B | 0016208 | molecular_function | AMP binding |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0032263 | biological_process | GMP salvage |
B | 0032264 | biological_process | IMP salvage |
B | 0034774 | cellular_component | secretory granule lumen |
B | 0044209 | biological_process | AMP salvage |
B | 0046083 | biological_process | adenine metabolic process |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
site_id | PS00103 |
Number of Residues | 13 |
Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VVVVDDLLATGgT |
Chain | Residue | Details |
A | VAL123-THR135 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195 |
Chain | Residue | Details |
A | SER4 | |
B | SER4 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER15 | |
B | SER15 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER30 | |
B | SER30 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195 |
Chain | Residue | Details |
A | TYR60 | |
B | TYR60 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER66 | |
B | SER66 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS114 | |
B | LYS114 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19369195 |
Chain | Residue | Details |
A | THR135 | |
B | THR135 |