6FD5
Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 days post crystallization (with AMP and PPi products partially generated)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Adenine phosphoribosyltransferase | polymer | 178 | 19411.5 | 2 | UniProt (P07741) Pfam (PF00156) In PDB | Homo sapiens (Human) | APRT |
| 2 | A, B | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) | |||
| 3 | A, B | PYROPHOSPHATE | non-polymer | 178.0 | 2 | Chemie (PPV) | |||
| 4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | B | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose | non-polymer | 390.1 | 1 | Chemie (PRP) | |||
| 7 | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 180 (UniProt: P07741)
| PDB | External Database | Details |
|---|---|---|
| Phe 105 | Tyr 105 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38822.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1581.2 | |
| All* | Total formula weight | 40404.1 |
