6FD5

Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 days post crystallization (with AMP and PPi products partially generated)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Adenine phosphoribosyltransferase	polymer	178	19411.5	2	UniProt (P07741) Pfam (PF00156)	Homo sapiens (Human)	APRT
2	C, H (A, B)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP) PubChem (224) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (5316444) PubChem (5742864) PubChem (12163610) PubChem (12358355) PubChem (16397049) PubChem (16760266) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (46875232) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (92144436) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (12358354) PubChem (122197642) PubChem (162290139) PubChem (162946266) PubChem (171699505)
3	D, J (A, B)	PYROPHOSPHATE	non-polymer		178.0	2	Chemie (PPV) PubChem (1023)
4	E, I (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG) PubChem (888)
5	F (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
6	G (B)	1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose	non-polymer		390.1	1	Chemie (PRP) PubChem (1041) PubChem (7339) PubChem (23616411) PubChem (24771812) PubChem (90395114) PubChem (92962115) PubChem (126970134)
7	K, L (A, B)	water	water		18.0	212	Chemie (HOH)

Sequence modifications

A, B: 3 - 180 (UniProt: P07741)

PDB	External Database	Details
Phe 105	Tyr 105	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38822.9
Non-Polymers*	Number of molecules	8
	Total formula weight	1581.2
All*	Total formula weight	40404.1

*Water molecules are not included.