6FD5
Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 days post crystallization (with AMP and PPi products partially generated)
Summary for 6FD5
Entry DOI | 10.2210/pdb6fd5/pdb |
Related | 6FCH 6FCI 6FCL 6FD4 6FD6 |
Descriptor | Adenine phosphoribosyltransferase, ADENOSINE MONOPHOSPHATE, PYROPHOSPHATE, ... (7 entities in total) |
Functional Keywords | rossman fold, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 40404.07 |
Authors | Nioche, P.,Huyet, J.,Ozeir, M. (deposition date: 2017-12-21, release date: 2018-08-15, Last modification date: 2024-01-17) |
Primary citation | Huyet, J.,Ozeir, M.,Burgevin, M.C.,Pinson, B.,Chesney, F.,Remy, J.M.,Siddiqi, A.R.,Lupoli, R.,Pinon, G.,Saint-Marc, C.,Gibert, J.F.,Morales, R.,Ceballos-Picot, I.,Barouki, R.,Daignan-Fornier, B.,Olivier-Bandini, A.,Auge, F.,Nioche, P. Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase. Cell Chem Biol, 25:666-676.e4, 2018 Cited by PubMed: 29576532DOI: 10.1016/j.chembiol.2018.02.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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