6FD5

Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 days post crystallization (with AMP and PPi products partially generated)

6FD5 の概要

• エントリーDOI: 10.2210/pdb6fd5/pdb
• 関連するPDBエントリー: 6FCH 6FCI 6FCL 6FD4 6FD6
• 分子名称: Adenine phosphoribosyltransferase, ADENOSINE MONOPHOSPHATE, PYROPHOSPHATE, ... (7 entities in total)
• 機能のキーワード: rossman fold, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40404.07

構造登録者

Nioche, P.,Huyet, J.,Ozeir, M. (登録日: 2017-12-21, 公開日: 2018-08-15, 最終更新日: 2024-01-17)

• 主引用文献: Huyet, J.,Ozeir, M.,Burgevin, M.C.,Pinson, B.,Chesney, F.,Remy, J.M.,Siddiqi, A.R.,Lupoli, R.,Pinon, G.,Saint-Marc, C.,Gibert, J.F.,Morales, R.,Ceballos-Picot, I.,Barouki, R.,Daignan-Fornier, B.,Olivier-Bandini, A.,Auge, F.,Nioche, P.; Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase.; Cell Chem Biol, 25:666-676.e4, 2018; PubMed: 29576532; DOI: 10.1016/j.chembiol.2018.02.011

実験手法