6F3D

IRAK4 IN COMPLEX WITH inhibitor

Summary for 6F3D

• Entry DOI: 10.2210/pdb6f3d/pdb
• Descriptor: Interleukin-1 receptor-associated kinase 4, SULFATE ION, 4-[4-[[4-(dimethylamino)cyclohexyl]amino]-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]cyclohexane-1-carboxamide, ... (4 entities in total)
• Functional Keywords: irak4, kinase, inhibitor, cancer, signaling protein
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q9NWZ3
• Total number of polymer chains: 2
• Total formula weight: 67592.49

Authors

Xue, Y.,Degorce, S.L.,Robb, G.R.,Ferguson, A.D. (deposition date: 2017-11-28, release date: 2018-05-23)

• Primary citation: Degorce, S.L.,Anjum, R.,Dillman, K.S.,Drew, L.,Groombridge, S.D.,Halsall, C.T.,Lenz, E.M.,Lindsay, N.A.,Mayo, M.F.,Pink, J.H.,Robb, G.R.,Scott, J.S.,Stokes, S.,Xue, Y.; Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.; Bioorg. Med. Chem., 26:913-924, 2018; PubMed: 29398441; DOI: 10.1016/j.bmc.2018.01.008

Experimental method

X-RAY DIFFRACTION (2.38 Å)