6F2L
Crystal structure of the complex between PPARgamma LBD and the ligand LJ570: structure obtained from crystals of the apo-form soaked for 15 days.
Summary for 6F2L
Entry DOI | 10.2210/pdb6f2l/pdb |
Related | 4JL4 |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid (3 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, complex with an agonist, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 69560.27 |
Authors | Pochetti, G.,Montanari, M. (deposition date: 2017-11-24, release date: 2018-01-10, Last modification date: 2024-02-07) |
Primary citation | Laghezza, A.,Piemontese, L.,Cerchia, C.,Montanari, R.,Capelli, D.,Giudici, M.,Crestani, M.,Tortorella, P.,Peiretti, F.,Pochetti, G.,Lavecchia, A.,Loiodice, F. Identification of the First PPAR alpha / gamma Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR gamma and To Inhibit Its Cdk5-Mediated Phosphorylation. J.Med.Chem., 61:8282-8298, 2018 Cited by PubMed: 30199253DOI: 10.1021/acs.jmedchem.8b00835 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report