6F2L

Crystal structure of the complex between PPARgamma LBD and the ligand LJ570: structure obtained from crystals of the apo-form soaked for 15 days.

Summary for 6F2L

Entry DOI	10.2210/pdb6f2l/pdb
Related	4JL4
Descriptor	Peroxisome proliferator-activated receptor gamma, (2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid (3 entities in total)
Functional Keywords	nuclear receptor, transcription factor, complex with an agonist, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	69560.27
Authors	Pochetti, G.,Montanari, M. (deposition date: 2017-11-24, release date: 2018-01-10, Last modification date: 2024-02-07)
Primary citation	Laghezza, A.,Piemontese, L.,Cerchia, C.,Montanari, R.,Capelli, D.,Giudici, M.,Crestani, M.,Tortorella, P.,Peiretti, F.,Pochetti, G.,Lavecchia, A.,Loiodice, F. Identification of the First PPAR alpha / gamma Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR gamma and To Inhibit Its Cdk5-Mediated Phosphorylation. J.Med.Chem., 61:8282-8298, 2018 Cited by PubMed: 30199253 DOI: 10.1021/acs.jmedchem.8b00835 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation