6F0W

prolyl hydroxylase in complex with hypoxia inducible factor oxygen degradation domain peptide fragment from Trichoplax adhaerens

6F0W の概要

• エントリーDOI: 10.2210/pdb6f0w/pdb
• 関連するPDBエントリー: 6YE1
• 分子名称: HIF prolyl hydroxylase, Hypoxia inducible factor, alpha subunit, N-OXALYLGLYCINE, ... (5 entities in total)
• 機能のキーワード: prolyl hydroxylase, oxygenase, oxidoreductase, oxygen sensing, hypoxia inducible factor
• 由来する生物種: Trichoplax adhaerens (Trichoplax reptans); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31896.81

構造登録者

McDonough, M.A.,Boleininger, A.,Schofield, C.J. (登録日: 2017-11-20, 公開日: 2018-10-03, 最終更新日: 2024-11-20)

主引用文献

Lippl, K.,Boleininger, A.,McDonough, M.A.,Abboud, M.I.,Tarhonskaya, H.,Chowdhury, R.,Loenarz, C.,Schofield, C.J.
Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens.
Hypoxia (Auckl), 6:57-71, 2018

PubMed Abstract: In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that counteract the effects of limiting oxygen. Prolyl hydroxylases (PHDs) act as hypoxia sensors for the HIF system in organisms ranging from humans to the simplest animal .

PubMed: 30519597
DOI: 10.2147/HP.S174655

実験手法

X-RAY DIFFRACTION (1.301 Å)