6F0A
Crystal structure of human indoleamine 2,3-dioxygenase bound to a triazole inhibitor and alanine molecule.
Summary for 6F0A
Entry DOI | 10.2210/pdb6f0a/pdb |
Descriptor | Indoleamine 2,3-dioxygenase 1, ~{N}-(4-chlorophenyl)-1~{H}-1,2,3-triazol-5-amine, ALANINE, ... (5 entities in total) |
Functional Keywords | tryptophan 2 3 dioxygenase activity electron transfer activity oxidoreductase activity heme binding indoleamine 2 3 dioxygenase activity metal ion binding dioxygenase activity, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 90248.22 |
Authors | Swan, M.K.,Latchem, M. (deposition date: 2017-11-17, release date: 2017-12-27, Last modification date: 2024-01-17) |
Primary citation | Alexandre, J.A.C.,Swan, M.K.,Latchem, M.J.,Boyall, D.,Pollard, J.R.,Hughes, S.W.,Westcott, J. New 4-Amino-1,2,3-Triazole Inhibitors of Indoleamine 2,3-Dioxygenase Form a Long-Lived Complex with the Enzyme and Display Exquisite Cellular Potency. Chembiochem, 19:552-561, 2018 Cited by PubMed: 29240291DOI: 10.1002/cbic.201700560 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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