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6F0A

Crystal structure of human indoleamine 2,3-dioxygenase bound to a triazole inhibitor and alanine molecule.

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0002666biological_processpositive regulation of T cell tolerance induction
A0002678biological_processpositive regulation of chronic inflammatory response
A0002830biological_processpositive regulation of type 2 immune response
A0004833molecular_functiontryptophan 2,3-dioxygenase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006569biological_processtryptophan catabolic process
A0006954biological_processinflammatory response
A0007565biological_processfemale pregnancy
A0009055molecular_functionelectron transfer activity
A0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A0019441biological_processtryptophan catabolic process to kynurenine
A0020037molecular_functionheme binding
A0030485cellular_componentsmooth muscle contractile fiber
A0032421cellular_componentstereocilium bundle
A0032496biological_processresponse to lipopolysaccharide
A0032693biological_processnegative regulation of interleukin-10 production
A0032735biological_processpositive regulation of interleukin-12 production
A0033555biological_processmulticellular organismal response to stress
A0033754molecular_functionindoleamine 2,3-dioxygenase activity
A0034276biological_processkynurenic acid biosynthetic process
A0034354biological_process'de novo' NAD biosynthetic process from tryptophan
A0036269biological_processswimming behavior
A0042098biological_processT cell proliferation
A0042130biological_processnegative regulation of T cell proliferation
A0043065biological_processpositive regulation of apoptotic process
A0046006biological_processregulation of activated T cell proliferation
A0046872molecular_functionmetal ion binding
A0051213molecular_functiondioxygenase activity
A0070233biological_processnegative regulation of T cell apoptotic process
A0070234biological_processpositive regulation of T cell apoptotic process
C0002376biological_processimmune system process
C0002666biological_processpositive regulation of T cell tolerance induction
C0002678biological_processpositive regulation of chronic inflammatory response
C0002830biological_processpositive regulation of type 2 immune response
C0004833molecular_functiontryptophan 2,3-dioxygenase activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006569biological_processtryptophan catabolic process
C0006954biological_processinflammatory response
C0007565biological_processfemale pregnancy
C0009055molecular_functionelectron transfer activity
C0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
C0019441biological_processtryptophan catabolic process to kynurenine
C0020037molecular_functionheme binding
C0030485cellular_componentsmooth muscle contractile fiber
C0032421cellular_componentstereocilium bundle
C0032496biological_processresponse to lipopolysaccharide
C0032693biological_processnegative regulation of interleukin-10 production
C0032735biological_processpositive regulation of interleukin-12 production
C0033555biological_processmulticellular organismal response to stress
C0033754molecular_functionindoleamine 2,3-dioxygenase activity
C0034276biological_processkynurenic acid biosynthetic process
C0034354biological_process'de novo' NAD biosynthetic process from tryptophan
C0036269biological_processswimming behavior
C0042098biological_processT cell proliferation
C0042130biological_processnegative regulation of T cell proliferation
C0043065biological_processpositive regulation of apoptotic process
C0046006biological_processregulation of activated T cell proliferation
C0046872molecular_functionmetal ion binding
C0051213molecular_functiondioxygenase activity
C0070233biological_processnegative regulation of T cell apoptotic process
C0070234biological_processpositive regulation of T cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue C82 A 501
ChainResidue
ATYR126
AALA502
AHEM503
ACYS129
AVAL130
APHE163
APHE164
ASER167
AGLY262
ASER263
AALA264

site_idAC2
Number of Residues8
Detailsbinding site for residue ALA A 502
ChainResidue
APHE163
APHE226
AARG231
AILE354
AGLY378
ATHR379
AC82501
AHEM503

site_idAC3
Number of Residues26
Detailsbinding site for residue HEM A 503
ChainResidue
APHE163
ASER167
AVAL170
APHE214
APHE226
ASER263
AALA264
AGLY265
APHE270
AARG343
AHIS346
AILE349
AVAL350
ATYR353
AILE354
AGLY378
ATHR379
AGLY380
AGLY381
ATHR382
ALEU384
APHE387
AVAL391
AC82501
AALA502
AHOH646

site_idAC4
Number of Residues11
Detailsbinding site for residue C82 C 501
ChainResidue
CTYR126
CCYS129
CVAL130
CPHE163
CSER167
CLEU234
CGLY262
CSER263
CALA264
CALA502
CHEM503

site_idAC5
Number of Residues8
Detailsbinding site for residue ALA C 502
ChainResidue
CPHE163
CPHE226
CARG231
CILE354
CGLY378
CTHR379
CC82501
CHEM503

site_idAC6
Number of Residues26
Detailsbinding site for residue HEM C 503
ChainResidue
CTYR126
CPHE163
CSER167
CVAL170
CPHE214
CPHE226
CSER263
CALA264
CGLY265
CPHE270
CARG343
CHIS346
CILE349
CILE354
CGLY378
CTHR379
CGLY380
CGLY381
CTHR382
CLEU384
CPHE387
CVAL391
CC82501
CALA502
CHOH603
CHOH642

Functional Information from PROSITE/UniProt
site_idPS00876
Number of Residues11
DetailsIDO_1 Indoleamine 2,3-dioxygenase signature 1. GGSAGQSSvfQ
ChainResidueDetails
AGLY261-GLN271

site_idPS00877
Number of Residues14
DetailsIDO_2 Indoleamine 2,3-dioxygenase signature 2. FLQDMrrYMppaHR
ChainResidueDetails
APHE291-ARG304

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: proximal binding residue => ECO:0000269|PubMed:16477023, ECO:0000269|PubMed:25313323, ECO:0007744|PDB:2D0T, ECO:0007744|PDB:2D0U, ECO:0007744|PDB:4PK5, ECO:0007744|PDB:4PK6
ChainResidueDetails
AHIS346
CHIS346

223532

PDB entries from 2024-08-07

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