6F0A

Crystal structure of human indoleamine 2,3-dioxygenase bound to a triazole inhibitor and alanine molecule.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006569	biological_process	L-tryptophan catabolic process
A	0007565	biological_process	female pregnancy
A	0009055	molecular_function	electron transfer activity
A	0016491	molecular_function	oxidoreductase activity
A	0019441	biological_process	obsolete L-tryptophan catabolic process to L-kynurenine
A	0019805	biological_process	quinolinate biosynthetic process
A	0020037	molecular_function	heme binding
A	0030485	cellular_component	smooth muscle contractile fiber
A	0032421	cellular_component	stereocilium bundle
A	0033754	molecular_function	indoleamine 2,3-dioxygenase activity
A	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
A	0046006	biological_process	regulation of activated T cell proliferation
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0070234	biological_process	positive regulation of T cell apoptotic process
C	0002376	biological_process	immune system process
C	0004833	molecular_function	L-tryptophan 2,3-dioxygenase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006569	biological_process	L-tryptophan catabolic process
C	0007565	biological_process	female pregnancy
C	0009055	molecular_function	electron transfer activity
C	0016491	molecular_function	oxidoreductase activity
C	0019441	biological_process	obsolete L-tryptophan catabolic process to L-kynurenine
C	0019805	biological_process	quinolinate biosynthetic process
C	0020037	molecular_function	heme binding
C	0030485	cellular_component	smooth muscle contractile fiber
C	0032421	cellular_component	stereocilium bundle
C	0033754	molecular_function	indoleamine 2,3-dioxygenase activity
C	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
C	0046006	biological_process	regulation of activated T cell proliferation
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	0070234	biological_process	positive regulation of T cell apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue C82 A 501

Chain	Residue
A	TYR126
A	ALA502
A	HEM503
A	CYS129
A	VAL130
A	PHE163
A	PHE164
A	SER167
A	GLY262
A	SER263
A	ALA264

---

site_id	AC2
Number of Residues	8
Details	binding site for residue ALA A 502

Chain	Residue
A	PHE163
A	PHE226
A	ARG231
A	ILE354
A	GLY378
A	THR379
A	C82501
A	HEM503

---

site_id	AC3
Number of Residues	26
Details	binding site for residue HEM A 503

Chain	Residue
A	PHE163
A	SER167
A	VAL170
A	PHE214
A	PHE226
A	SER263
A	ALA264
A	GLY265
A	PHE270
A	ARG343
A	HIS346
A	ILE349
A	VAL350
A	TYR353
A	ILE354
A	GLY378
A	THR379
A	GLY380
A	GLY381
A	THR382
A	LEU384
A	PHE387
A	VAL391
A	C82501
A	ALA502
A	HOH646

---

site_id	AC4
Number of Residues	11
Details	binding site for residue C82 C 501

Chain	Residue
C	TYR126
C	CYS129
C	VAL130
C	PHE163
C	SER167
C	LEU234
C	GLY262
C	SER263
C	ALA264
C	ALA502
C	HEM503

---

site_id	AC5
Number of Residues	8
Details	binding site for residue ALA C 502

Chain	Residue
C	PHE163
C	PHE226
C	ARG231
C	ILE354
C	GLY378
C	THR379
C	C82501
C	HEM503

---

site_id	AC6
Number of Residues	26
Details	binding site for residue HEM C 503

Chain	Residue
C	TYR126
C	PHE163
C	SER167
C	VAL170
C	PHE214
C	PHE226
C	SER263
C	ALA264
C	GLY265
C	PHE270
C	ARG343
C	HIS346
C	ILE349
C	ILE354
C	GLY378
C	THR379
C	GLY380
C	GLY381
C	THR382
C	LEU384
C	PHE387
C	VAL391
C	C82501
C	ALA502
C	HOH603
C	HOH642

---

Functional Information from PROSITE/UniProt

site_id	PS00876
Number of Residues	11
Details	IDO_1 Indoleamine 2,3-dioxygenase signature 1. GGSAGQSSvfQ

Chain	Residue	Details
A	GLY261-GLN271

---

site_id	PS00877
Number of Residues	14
Details	IDO_2 Indoleamine 2,3-dioxygenase signature 2. FLQDMrrYMppaHR

Chain	Residue	Details
A	PHE291-ARG304

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"description":"proximal binding residue","evidences":[{"source":"PubMed","id":"16477023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25313323","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D0U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PK6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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