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6EY2

Crystal structure of XIAP-BIR3 in complex with a cIAP1-selective SM

Summary for 6EY2
Entry DOI10.2210/pdb6ey2/pdb
DescriptorE3 ubiquitin-protein ligase XIAP, ZINC ION, (3~{S},6~{S},7~{S},9~{a}~{S})-~{N}-[(4-~{tert}-butylphenyl)methyl]-7-(hydroxymethyl)-6-[[(2~{S})-2-(methylamino)butanoyl]amino]-5-oxidanylidene-1,2,3,6,7,8,9,9~{a}-octahydropyrrolo[1,2-a]azepine-3-carboxamide, ... (4 entities in total)
Functional Keywordszinc finger motif, smac-mimetic, protein-ligand complex, bir domain, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total formula weight136290.92
Authors
Cossu, F.,Corti, A.,Milani, M.,Mastrangelo, E. (deposition date: 2017-11-10, release date: 2018-08-08, Last modification date: 2024-01-17)
Primary citationCorti, A.,Milani, M.,Lecis, D.,Seneci, P.,de Rosa, M.,Mastrangelo, E.,Cossu, F.
Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs.
FEBS J., 285:3286-3298, 2018
Cited by
PubMed: 30055105
DOI: 10.1111/febs.14616
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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