6EY2

Crystal structure of XIAP-BIR3 in complex with a cIAP1-selective SM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity
C	0003824	molecular_function	catalytic activity
D	0003824	molecular_function	catalytic activity
E	0003824	molecular_function	catalytic activity
F	0003824	molecular_function	catalytic activity
G	0003824	molecular_function	catalytic activity
H	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS300
A	CYS303
A	HIS320
A	CYS327

---

site_id	AC2
Number of Residues	14
Details	binding site for residue C3T A 402

Chain	Residue
A	THR308
A	ASP309
A	TRP310
A	GLU314
A	GLN319
A	TRP323
C	THR345
C	GLU349
C	LEU352
A	LEU292
A	LYS299
A	GLY304
A	GLY306
A	LEU307

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 401

Chain	Residue
B	CYS300
B	CYS303
B	HIS320
B	CYS327

---

site_id	AC4
Number of Residues	12
Details	binding site for residue C3T B 402

Chain	Residue
B	LEU292
B	LYS299
B	GLY304
B	GLY306
B	LEU307
B	THR308
B	ASP309
B	GLU314
B	TRP323
G	THR345
G	LEU348
G	LEU352

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN C 401

Chain	Residue
C	CYS300
C	CYS303
C	HIS320
C	CYS327

---

site_id	AC6
Number of Residues	13
Details	binding site for residue C3T C 402

Chain	Residue
C	LYS297
C	GLY306
C	LEU307
C	THR308
C	ASP309
C	TRP310
C	GLU314
C	GLN319
C	TYR324
F	GLU318
F	LYS322
F	ILE342
F	GLU349

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN D 401

Chain	Residue
D	CYS300
D	CYS303
D	HIS320
D	CYS327

---

site_id	AC8
Number of Residues	14
Details	binding site for residue C3T D 402

Chain	Residue
B	THR345
B	LEU348
B	GLU349
D	LEU292
D	LYS299
D	GLY306
D	LEU307
D	THR308
D	ASP309
D	TRP310
D	GLU314
D	GLN319
D	TRP323
D	TYR324

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN E 401

Chain	Residue
E	CYS300
E	CYS303
E	HIS320
E	CYS327

---

site_id	AD1
Number of Residues	10
Details	binding site for residue C3T E 402

Chain	Residue
D	GLU318
D	GLU349
E	GLY306
E	LEU307
E	THR308
E	ASP309
E	GLU314
E	TRP323
E	TYR324
E	HOH502

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN F 401

Chain	Residue
F	CYS300
F	CYS303
F	HIS320
F	CYS327

---

site_id	AD3
Number of Residues	12
Details	binding site for residue C3T F 402

Chain	Residue
F	LEU292
F	GLY306
F	THR308
F	ASP309
F	TRP310
F	GLU314
F	GLN319
F	TRP323
F	TYR324
H	THR345
H	GLU349
H	LEU352

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN G 401

Chain	Residue
G	CYS300
G	CYS303
G	HIS320
G	CYS327

---

site_id	AD5
Number of Residues	9
Details	binding site for residue C3T G 402

Chain	Residue
E	THR345
E	GLU349
G	GLY306
G	LEU307
G	THR308
G	ASP309
G	GLU314
G	TRP323
G	TYR324

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN H 401

Chain	Residue
H	CYS300
H	CYS303
H	HIS320
H	CYS327

---

site_id	AD7
Number of Residues	11
Details	binding site for residue C3T H 402

Chain	Residue
A	THR345
H	LYS299
H	GLY306
H	LEU307
H	THR308
H	ASP309
H	TRP310
H	GLU314
H	GLN319
H	TRP323
H	TYR324

---

Functional Information from PROSITE/UniProt

site_id	PS01282
Number of Residues	66
Details	BIR_REPEAT_1 BIR repeat. YeaRiftfgt.Wiysvnkeqlar...AGFyAlgegDkvkCfhCgggltdWkpsedpweqHakwyPgCkyL

Chain	Residue	Details
A	TYR265-LEU330

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	520
Details	Repeat: {"description":"BIR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	120
Details	Region: {"description":"Required for interaction with SEPTIN4 isoform ARTS","evidences":[{"source":"PubMed","id":"21695558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	168
Details	Region: {"description":"Required for interaction with DIABLO","evidences":[{"source":"PubMed","id":"21695558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00029","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"12747801","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---