6EXW

Crystal structure of cIAP1-BIR3 in complex with a covalently bound SM

Summary for 6EXW

Entry DOI	10.2210/pdb6exw/pdb
Related	3MUP
Descriptor	Baculoviral IAP repeat-containing protein 2, ZINC ION, (3~{S},6~{S},7~{R},9~{a}~{S})-6-[[(2~{S})-2-(methylamino)propanoyl]amino]-5-oxidanylidene-~{N}-(phenylmethyl)-7-[(propanoylamino)methyl]-3,6,7,8,9,9~{a}-hexahydropyrrolo[1,2-a]azepine-3-carboxamide, ... (4 entities in total)
Functional Keywords	zinc finger motif, smac-mimetic, protein-ligand complex, bir domain, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	29850.45
Authors	Corti, A.,Cossu, F.,Milani, M.,Mastrangelo, E. (deposition date: 2017-11-10, release date: 2018-08-08, Last modification date: 2024-01-17)
Primary citation	Corti, A.,Milani, M.,Lecis, D.,Seneci, P.,de Rosa, M.,Mastrangelo, E.,Cossu, F. Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs. FEBS J., 285:3286-3298, 2018 Cited by PubMed: 30055105 DOI: 10.1111/febs.14616 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation