6EXW

Crystal structure of cIAP1-BIR3 in complex with a covalently bound SM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Baculoviral IAP repeat-containing protein 2	polymer	122	14390.2	2	UniProt (Q13490) Pfam (PF00653) In PDB	Homo sapiens (Human)	Cellular inhibitor of apoptosis 1,C-IAP1,IAP homolog B,Inhibitor of apoptosis protein 2,hIAP2,RING finger protein 48,RING-type E3 ubiquitin transferase BIRC2,TNFR2-TRAF-signaling complex protein 2
2	A, C	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	A, C	(3~{S},6~{S},7~{R},9~{a}~{S})-6-[[(2~{S})-2-(methylamino)propanoyl]amino]-5-oxidanylidene-~{N}-(phenylmethyl)-7-[(propanoylamino)methyl]-3,6,7,8,9,9~{a}-hexahydropyrrolo[1,2-a]azepine-3-carboxamide	non-polymer		469.6	2	Chemie (C3K)
4		water	water		18.0	155	Chemie (HOH)

Sequence modifications

A, C: 245 - 357 (UniProt: Q13490)

PDB	External Database	Details
Met 244	-	initiating methionine
Leu 358	-	expression tag
Glu 359	-	expression tag
His 360	-	expression tag
His 361	-	expression tag
His 362	-	expression tag
His 363	-	expression tag
His 364	-	expression tag
His 365	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	28780.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1070.0
All*	Total formula weight	29850.5

*Water molecules are not included.