6EXM
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (MK202)
Summary for 6EXM
Entry DOI | 10.2210/pdb6exm/pdb |
Related | 5F1R |
Descriptor | Listeriolysin positive regulatory factor A, [(3~{R})-3-carboxy-7-[(2,3-dimethylphenyl)methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium, SODIUM ION, ... (5 entities in total) |
Functional Keywords | transcription regulator, dna binding, 2-pyridone, drug design, listeria monocytogenes, dna binding protein |
Biological source | Listeria monocytogenes |
Total number of polymer chains | 2 |
Total formula weight | 55943.32 |
Authors | Grundstrom, C.,Begum, A.,Hall, M.,Kulen, M.,Lindgren, M.,Johansson, J.,Almqvist, F.,Sauer, U.H.,Sauer-Eriksson, A.E. (deposition date: 2017-11-08, release date: 2018-05-02, Last modification date: 2024-01-17) |
Primary citation | Kulen, M.,Lindgren, M.,Hansen, S.,Cairns, A.G.,Grundstrom, C.,Begum, A.,van der Lingen, I.,Brannstrom, K.,Hall, M.,Sauer, U.H.,Johansson, J.,Sauer-Eriksson, A.E.,Almqvist, F. Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes. J. Med. Chem., 61:4165-4175, 2018 Cited by PubMed: 29667825DOI: 10.1021/acs.jmedchem.8b00289 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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