6EVQ
solution NMR structure of EB1 C terminus (191-260) with a small molecule bound into the SxIP binding site
Summary for 6EVQ
| Entry DOI | 10.2210/pdb6evq/pdb |
| Descriptor | Microtubule-associated protein RP/EB family member 1, (2~{R})-2-[(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)sulfanyl]-~{N}-(furan-2-ylmethyl)propanamide (2 entities in total) |
| Functional Keywords | end-binding protein, eb1, microtubules, sxip, microtubule-associated protein rp/eb family member 1, mapre1, apc-binding protein eb1, protein binding |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 2 |
| Total formula weight | 16742.75 |
| Authors | Barsukov, I.L.,Almeida, T.B. (deposition date: 2017-11-02, release date: 2018-02-07, Last modification date: 2019-05-08) |
| Primary citation | Almeida, T.B.,Carnell, A.J.,Barsukov, I.L.,Berry, N.G. Targeting SxIP-EB1 interaction: An integrated approach to the discovery of small molecule modulators of dynamic binding sites. Sci Rep, 7:15533-15533, 2017 Cited by PubMed: 29138501DOI: 10.1038/s41598-017-15502-6 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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