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6EUW

Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor

Summary for 6EUW
Entry DOI10.2210/pdb6euw/pdb
DescriptorPolymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, ... (4 entities in total)
Functional Keywordsinfluenza rna-dependent rna polymerase, pb2 subunit, cap-binding domain, inhibitor, rna binding protein
Biological sourceInfluenza A virus (A/duck/Shantou/4610/2003(H5N1))
Cellular locationHost nucleus : Q2LG68
Total number of polymer chains1
Total formula weight18832.77
Authors
Cusack, S.,Gaudon, S. (deposition date: 2017-10-31, release date: 2017-12-13, Last modification date: 2024-01-17)
Primary citationPflug, A.,Gaudon, S.,Resa-Infante, P.,Lethier, M.,Reich, S.,Schulze, W.M.,Cusack, S.
Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46:956-971, 2018
Cited by
PubMed: 29202182
DOI: 10.1093/nar/gkx1210
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1 Å)
Structure validation

217705

건을2024-03-27부터공개중

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