6EUW
Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Polymerase basic protein 2 | polymer | 163 | 18248.2 | 1 | UniProt (Q2LG68) Pfam (PF00604) In PDB | Influenza A virus (A/duck/Shantou/4610/2003(H5N1)) | |
| 2 | A | (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid | non-polymer | 400.4 | 1 | Chemie (BYB) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A: 318 - 479 (UniProt: Q2LG68)
| PDB | External Database | Details |
|---|---|---|
| Gly 317 | - | expression tag |
| Gly 421 | Val 421 | engineered mutation |
| - | Asn 422 | deletion |
| - | Arg 423 | deletion |
| - | Ala 424 | deletion |
| - | Asn 425 | deletion |
| Ser 422 | Gln 426 | engineered mutation |
| Gly 423 | Arg 427 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18248.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 584.6 | |
| All* | Total formula weight | 18832.8 |
