6EUV

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)

6EUV の概要

• エントリーDOI: 10.2210/pdb6euv/pdb
• 分子名称: Polymerase basic protein 2, (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, ... (4 entities in total)
• 機能のキーワード: influenza a polymerase, pb2 subunit, cap-binding domain, cap-binding inhibitor, rna binding protein
• 由来する生物種: Influenza A virus (strain A/Victoria/3/1975 H3N2)
• 細胞内の位置: Virion : P31345
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132728.42

構造登録者

Cusack, S.,Lethier, M. (登録日: 2017-10-31, 公開日: 2017-12-13, 最終更新日: 2024-01-17)

• 主引用文献: Pflug, A.,Gaudon, S.,Resa-Infante, P.,Lethier, M.,Reich, S.,Schulze, W.M.,Cusack, S.; Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.; Nucleic Acids Res., 46:956-971, 2018; PubMed: 29202182; DOI: 10.1093/nar/gkx1210

実験手法

X-RAY DIFFRACTION (2.7 Å)