6ET9

Structure of the acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex from Methanothermococcus thermolithotrophicus at 2.75 A

6ET9 の概要

• エントリーDOI: 10.2210/pdb6et9/pdb
• 分子名称: Acetyl-CoA acetyltransferase thiolase, ZINC ION, Pfam DUF35, ... (11 entities in total)
• 機能のキーワード: isoprenoid synthesis, enzymatic channeling, mevalonate production, archaea, lipid biosynthesis, multi-enzymatic complex, scaffold protein, duf35 family, transferase
• 由来する生物種: Methanothermococcus thermolithotrophicus; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 380273.98

構造登録者

Engilberge, S.,Voegeli, B.,Girard, E.,Riobe, F.,Maury, O.,Erb, T.J.,Shima, S.,Wagner, T. (登録日: 2017-10-25, 公開日: 2018-03-14, 最終更新日: 2018-04-11)

• 主引用文献: Vogeli, B.,Engilberge, S.,Girard, E.,Riobe, F.,Maury, O.,Erb, T.J.,Shima, S.,Wagner, T.; Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.; Proc. Natl. Acad. Sci. U.S.A., 115:3380-3385, 2018; PubMed: 29531083; DOI: 10.1073/pnas.1718649115

実験手法

X-RAY DIFFRACTION (2.75 Å)