6ES0
Crystal structure of the kinase domain of human RIPK2 in complex with the activation loop targeting inhibitor CS-R35
Summary for 6ES0
| Entry DOI | 10.2210/pdb6es0/pdb |
| Descriptor | Receptor-interacting serine/threonine-protein kinase 2, 2-[2-fluoranyl-4-[[2-fluoranyl-4-[2-(methylcarbamoyl)pyridin-4-yl]oxy-phenyl]carbamoylamino]phenyl]sulfanylethanoic acid (3 entities in total) |
| Functional Keywords | kinase inhibitor, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 73748.63 |
| Authors | Pinkas, D.M.,Bufton, J.C.,Suebsuwong, C.,Ray, S.S.,Dai, B.,Newman, J.A.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Degterev, A.,Cuny, G.D.,Bullock, A.N. (deposition date: 2017-10-19, release date: 2018-02-21, Last modification date: 2024-01-17) |
| Primary citation | Suebsuwong, C.,Pinkas, D.M.,Ray, S.S.,Bufton, J.C.,Dai, B.,Bullock, A.N.,Degterev, A.,Cuny, G.D. Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors. Bioorg. Med. Chem. Lett., 28:577-583, 2018 Cited by PubMed: 29409752DOI: 10.1016/j.bmcl.2018.01.044 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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