6ES0
Crystal structure of the kinase domain of human RIPK2 in complex with the activation loop targeting inhibitor CS-R35
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Receptor-interacting serine/threonine-protein kinase 2 | polymer | 317 | 36385.9 | 2 | UniProt (O43353) Pfam (PF07714) In PDB | Homo sapiens (Human) | CARD-containing interleukin-1 beta-converting enzyme-associated kinase,CARD-containing IL-1 beta ICE-kinase,RIP-like-interacting CLARP kinase,Receptor-interacting protein 2,RIP-2,Tyrosine-protein kinase RIPK2 |
| 2 | A, B | 2-[2-fluoranyl-4-[[2-fluoranyl-4-[2-(methylcarbamoyl)pyridin-4-yl]oxy-phenyl]carbamoylamino]phenyl]sulfanylethanoic acid | non-polymer | 488.5 | 2 | Chemie (BW8) | |||
| 3 | water | water | 18.0 | 195 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 317 (UniProt: O43353)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| Met 2 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72771.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 976.9 | |
| All* | Total formula weight | 73748.6 |
