6EQC

Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon

Summary for 6EQC

• Entry DOI: 10.2210/pdb6eqc/pdb
• Related: 5OGI
• EMDB information: 3821
• Descriptor: Hexon protein, scFv of 9C12 antibody (2 entities in total)
• Functional Keywords: antibody, human adenovirus c5, gene therapy viral protein, viral protein
• Biological source: Mus musculus (House Mouse); More
• Cellular location: Virion : P04133
• Total number of polymer chains: 6
• Total formula weight: 405896.08

Authors

Schmid, M.,Ernst, P.,Honegger, A.,Suomalainen, M.,Zimmermann, M.,Braun, L.,Stauffer, S.,Thom, C.,Dreier, B.,Eibauer, M.,Kipar, A.,Vogel, V.,Greber, U.F.,Medalia, O.,Plueckthun, A. (deposition date: 2017-10-12, release date: 2018-02-07, Last modification date: 2018-02-14)

• Primary citation: Schmid, M.,Ernst, P.,Honegger, A.,Suomalainen, M.,Zimmermann, M.,Braun, L.,Stauffer, S.,Thom, C.,Dreier, B.,Eibauer, M.,Kipar, A.,Vogel, V.,Greber, U.F.,Medalia, O.,Pluckthun, A.; Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.; Nat Commun, 9:450-450, 2018; PubMed: 29386504; DOI: 10.1038/s41467-017-02707-6

Experimental method

ELECTRON MICROSCOPY (7.4 Å)