6EPA

Structure of dNCS-1 bound to the NCS-1/Ric8a protein/protein interaction regulator IGS-1.76

6EPA の概要

• エントリーDOI: 10.2210/pdb6epa/pdb
• 分子名称: FI18190p1, CALCIUM ION, ~{N}-(1,3-benzothiazol-2-yl)-3,3-diphenyl-propanamide, ... (6 entities in total)
• 機能のキーワード: calcium sensor, synapse regulation, signaling protein
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22544.27

構造登録者

Sanchez-Barrena, M.J.,Daniel, M.,Infantes, L. (登録日: 2017-10-11, 公開日: 2018-08-29, 最終更新日: 2024-01-17)

• 主引用文献: Roca, C.,Martinez-Gonzalez, L.,Daniel-Mozo, M.,Sastre, J.,Infantes, L.,Mansilla, A.,Chaves-Sanjuan, A.,Gonzalez-Rubio, J.M.,Gil, C.,Canada, F.J.,Martinez, A.,Sanchez-Barrena, M.J.,Campillo, N.E.; Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators.; J. Med. Chem., 61:5910-5921, 2018; PubMed: 29966094; DOI: 10.1021/acs.jmedchem.8b00088

実験手法

X-RAY DIFFRACTION (1.82 Å)