6EP8

InhA Y158F mutant in complex with NADH from Mycobacterium tuberculosis

6EP8 の概要

• エントリーDOI: 10.2210/pdb6ep8/pdb
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], SODIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (6 entities in total)
• 機能のキーワード: mycolic acid biosynthetic process, oxidoreductase, therapeutic target, isoniazid, mutation, catalytic mechanism, enoyl thioester reductases, tuberculosis
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30247.18

構造登録者

Wagner, T.,Voegeli, B.,Rosenthal, R.G.,Stoffel, G.,Shima, S.,Kiefer, P.,Cortina, N.,Erb, T.J. (登録日: 2017-10-11, 公開日: 2018-09-19, 最終更新日: 2024-01-17)

• 主引用文献: Vogeli, B.,Rosenthal, R.G.,Stoffel, G.M.M.,Wagner, T.,Kiefer, P.,Cortina, N.S.,Shima, S.,Erb, T.J.; InhA, the enoyl-thioester reductase fromMycobacterium tuberculosisforms a covalent adduct during catalysis.; J. Biol. Chem., 293:17200-17207, 2018; PubMed: 30217823; DOI: 10.1074/jbc.RA118.005405

実験手法

X-RAY DIFFRACTION (1.8 Å)