6EOR
DPP9 - 1G244
Summary for 6EOR
Entry DOI | 10.2210/pdb6eor/pdb |
Descriptor | Dipeptidyl peptidase 9, (2~{S})-2-azanyl-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione (3 entities in total) |
Functional Keywords | dpp9, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 1: Cytoplasm, cytosol . Isoform 2: Nucleus : Q86TI2 |
Total number of polymer chains | 4 |
Total formula weight | 398871.13 |
Authors | Ross, B.R.,Huber, R. (deposition date: 2017-10-10, release date: 2018-02-07, Last modification date: 2024-01-17) |
Primary citation | Ross, B.,Krapp, S.,Augustin, M.,Kierfersauer, R.,Arciniega, M.,Geiss-Friedlander, R.,Huber, R. Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc. Natl. Acad. Sci. U.S.A., 115:E1437-E1445, 2018 Cited by PubMed: 29382749DOI: 10.1073/pnas.1717565115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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