6EOR

DPP9 - 1G244

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005874	cellular_component	microtubule
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0008239	molecular_function	dipeptidyl-peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0031252	cellular_component	cell leading edge
A	0042802	molecular_function	identical protein binding
A	0043069	biological_process	negative regulation of programmed cell death
A	0051604	biological_process	protein maturation
A	0070269	biological_process	pyroptotic inflammatory response
A	0140633	biological_process	CARD8 inflammasome complex assembly
A	0141201	biological_process	pyroptotic cell death
A	1904784	biological_process	NLRP1 inflammasome complex assembly
B	0004177	molecular_function	aminopeptidase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005874	cellular_component	microtubule
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0008239	molecular_function	dipeptidyl-peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0031252	cellular_component	cell leading edge
B	0042802	molecular_function	identical protein binding
B	0043069	biological_process	negative regulation of programmed cell death
B	0051604	biological_process	protein maturation
B	0070269	biological_process	pyroptotic inflammatory response
B	0140633	biological_process	CARD8 inflammasome complex assembly
B	0141201	biological_process	pyroptotic cell death
B	1904784	biological_process	NLRP1 inflammasome complex assembly
C	0004177	molecular_function	aminopeptidase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005874	cellular_component	microtubule
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0008239	molecular_function	dipeptidyl-peptidase activity
C	0016787	molecular_function	hydrolase activity
C	0031252	cellular_component	cell leading edge
C	0042802	molecular_function	identical protein binding
C	0043069	biological_process	negative regulation of programmed cell death
C	0051604	biological_process	protein maturation
C	0070269	biological_process	pyroptotic inflammatory response
C	0140633	biological_process	CARD8 inflammasome complex assembly
C	0141201	biological_process	pyroptotic cell death
C	1904784	biological_process	NLRP1 inflammasome complex assembly
D	0004177	molecular_function	aminopeptidase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005874	cellular_component	microtubule
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0008239	molecular_function	dipeptidyl-peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0031252	cellular_component	cell leading edge
D	0042802	molecular_function	identical protein binding
D	0043069	biological_process	negative regulation of programmed cell death
D	0051604	biological_process	protein maturation
D	0070269	biological_process	pyroptotic inflammatory response
D	0140633	biological_process	CARD8 inflammasome complex assembly
D	0141201	biological_process	pyroptotic cell death
D	1904784	biological_process	NLRP1 inflammasome complex assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue 9XH A 901

Chain	Residue
A	ARG133
A	TYR766
A	ASN810
A	VAL811
A	HIS840
A	HOH1029
A	HOH1036
A	HOH1056
A	GLU248
A	GLU249
A	TYR644
A	GLN648
A	SER730
A	TYR731
A	VAL756
A	TYR762

---

site_id	AC2
Number of Residues	15
Details	binding site for residue 9XH B 901

Chain	Residue
B	ARG133
B	GLU248
B	GLU249
B	TYR644
B	GLN648
B	SER730
B	TYR731
B	VAL756
B	TRP759
B	TYR762
B	TYR766
B	ASN810
B	VAL811
B	HOH1019
B	HOH1027

---

site_id	AC3
Number of Residues	12
Details	binding site for residue 9XH C 901

Chain	Residue
C	ARG133
C	GLU248
C	GLU249
C	TYR644
C	GLN648
C	SER730
C	TYR731
C	VAL756
C	TRP759
C	TYR762
C	TYR766
C	ASN810

---

site_id	AC4
Number of Residues	16
Details	binding site for residue 9XH D 901

Chain	Residue
D	ARG133
D	GLU248
D	GLU249
D	TYR644
D	GLN648
D	VAL649
D	SER730
D	TYR731
D	VAL756
D	TRP759
D	TYR762
D	TYR766
D	ASN810
D	VAL811
D	HIS840
D	SER841

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"30291141","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"Q6V1X1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"33731932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34019797","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JN7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---