6EO0

Zebrafish Sirt5 in complex with stalled peptidylimidate and bicyclic intermediate of inhibitory compound 29

Summary for 6EO0

Entry DOI	10.2210/pdb6eo0/pdb
Descriptor	NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	hydrolase, ptm, inhibitor, signaling protein
Biological source	Danio rerio (Zebrafish)
Cellular location	Mitochondrion : Q6DHI5
Total number of polymer chains	4
Total formula weight	129146.92
Authors	Pannek, M.,Steegborn, C. (deposition date: 2017-10-08, release date: 2017-11-01, Last modification date: 2024-01-17)
Primary citation	Rajabi, N.,Auth, M.,Troelsen, K.R.,Pannek, M.,Bhatt, D.P.,Fontenas, M.,Hirschey, M.D.,Steegborn, C.,Madsen, A.S.,Olsen, C.A. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew. Chem. Int. Ed. Engl., 56:14836-14841, 2017 Cited by PubMed: 29044784 DOI: 10.1002/anie.201709050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation