6EO0
Zebrafish Sirt5 in complex with stalled peptidylimidate and bicyclic intermediate of inhibitory compound 29
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
A | 0070403 | molecular_function | NAD+ binding |
B | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
B | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
B | 0070403 | molecular_function | NAD+ binding |
C | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
C | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
C | 0070403 | molecular_function | NAD+ binding |
D | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
D | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
D | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 301 |
Chain | Residue |
A | CYS162 |
A | CYS165 |
A | CYS203 |
A | CYS208 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue EDO A 302 |
Chain | Residue |
A | GLU286 |
B | PRO69 |
site_id | AC3 |
Number of Residues | 31 |
Details | binding site for residue BV8 A 303 |
Chain | Residue |
A | ALA59 |
A | GLU60 |
A | THR65 |
A | PHE66 |
A | ARG67 |
A | TYR98 |
A | ARG101 |
A | GLN136 |
A | HIS154 |
A | VAL217 |
A | PHE219 |
A | GLY220 |
A | GLU221 |
A | THR222 |
A | LEU223 |
A | GLY245 |
A | THR246 |
A | SER247 |
A | VAL250 |
A | TYR251 |
A | ASN271 |
A | MET272 |
A | GLU273 |
A | CYS289 |
A | BVT304 |
C | TYR251 |
C | MET255 |
C | PHE256 |
A | GLY54 |
A | ALA55 |
A | GLY56 |
site_id | AC4 |
Number of Residues | 33 |
Details | binding site for residue BVT A 304 |
Chain | Residue |
A | GLY54 |
A | ALA55 |
A | GLY56 |
A | ALA59 |
A | GLU60 |
A | THR65 |
A | PHE66 |
A | ARG67 |
A | ALA82 |
A | TYR98 |
A | ARG101 |
A | GLN136 |
A | ILE138 |
A | HIS154 |
A | VAL217 |
A | PHE219 |
A | GLY220 |
A | GLU221 |
A | THR222 |
A | LEU223 |
A | GLY245 |
A | THR246 |
A | SER247 |
A | VAL250 |
A | TYR251 |
A | ASN271 |
A | MET272 |
A | GLU273 |
A | CYS289 |
A | BV8303 |
C | TYR251 |
C | MET255 |
C | PHE256 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN B 301 |
Chain | Residue |
B | CYS162 |
B | CYS165 |
B | CYS203 |
B | CYS208 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue EDO B 302 |
Chain | Residue |
A | LYS28 |
B | GLU85 |
B | ARG89 |
B | HOH409 |
D | SER262 |
site_id | AC7 |
Number of Residues | 36 |
Details | binding site for residue BVT B 303 |
Chain | Residue |
B | THR246 |
B | SER247 |
B | VAL250 |
B | TYR251 |
B | ASN271 |
B | MET272 |
B | GLU273 |
B | CYS289 |
D | LEU228 |
D | TYR251 |
D | MET255 |
D | PHE256 |
D | PRO258 |
D | GLN259 |
D | ARG280 |
D | EDO302 |
B | GLY54 |
B | ALA55 |
B | GLY56 |
B | ALA59 |
B | GLU60 |
B | THR65 |
B | PHE66 |
B | ARG67 |
B | ALA82 |
B | TYR98 |
B | ARG101 |
B | GLN136 |
B | ILE138 |
B | HIS154 |
B | VAL217 |
B | PHE219 |
B | GLY220 |
B | GLU221 |
B | THR222 |
B | GLY245 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue ZN C 301 |
Chain | Residue |
C | CYS162 |
C | CYS165 |
C | CYS203 |
C | CYS208 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue EDO C 302 |
Chain | Residue |
A | LEU228 |
C | LEU223 |
C | LEU228 |
site_id | AD1 |
Number of Residues | 37 |
Details | binding site for residue BVT C 303 |
Chain | Residue |
A | TYR251 |
A | MET255 |
A | PHE256 |
A | PRO258 |
A | GLN259 |
C | GLY54 |
C | ALA55 |
C | GLY56 |
C | ALA59 |
C | GLU60 |
C | THR65 |
C | PHE66 |
C | ARG67 |
C | ALA82 |
C | TYR98 |
C | ARG101 |
C | GLN136 |
C | ILE138 |
C | HIS154 |
C | VAL217 |
C | TRP218 |
C | PHE219 |
C | GLY220 |
C | GLU221 |
C | THR222 |
C | GLY245 |
C | THR246 |
C | SER247 |
C | VAL250 |
C | TYR251 |
C | ASN271 |
C | MET272 |
C | GLU273 |
C | CYS289 |
C | HOH405 |
C | HOH412 |
C | HOH422 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue ZN D 301 |
Chain | Residue |
D | CYS162 |
D | CYS165 |
D | CYS203 |
D | CYS208 |
site_id | AD3 |
Number of Residues | 2 |
Details | binding site for residue EDO D 302 |
Chain | Residue |
B | BVT303 |
D | HOH417 |
site_id | AD4 |
Number of Residues | 32 |
Details | binding site for residue BVT D 303 |
Chain | Residue |
B | MET255 |
B | PHE256 |
B | GLN259 |
D | GLY54 |
D | ALA55 |
D | GLY56 |
D | ALA59 |
D | THR65 |
D | PHE66 |
D | ARG67 |
D | ALA82 |
D | TYR98 |
D | ARG101 |
D | GLN136 |
D | HIS154 |
D | VAL216 |
D | VAL217 |
D | PHE219 |
D | GLY220 |
D | GLU221 |
D | THR222 |
D | GLY245 |
D | THR246 |
D | SER247 |
D | VAL250 |
D | TYR251 |
D | ASN271 |
D | MET272 |
D | GLU273 |
D | GLY287 |
D | PRO288 |
D | CYS289 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236 |
Chain | Residue | Details |
A | HIS154 | |
B | HIS154 | |
C | HIS154 | |
D | HIS154 |
site_id | SWS_FT_FI2 |
Number of Residues | 44 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160 |
Chain | Residue | Details |
A | GLY54 | |
A | ASN271 | |
A | CYS289 | |
B | GLY54 | |
B | TYR98 | |
B | ARG101 | |
B | GLN136 | |
B | CYS162 | |
B | CYS165 | |
B | CYS203 | |
B | CYS208 | |
A | TYR98 | |
B | GLY245 | |
B | ASN271 | |
B | CYS289 | |
C | GLY54 | |
C | TYR98 | |
C | ARG101 | |
C | GLN136 | |
C | CYS162 | |
C | CYS165 | |
C | CYS203 | |
A | ARG101 | |
C | CYS208 | |
C | GLY245 | |
C | ASN271 | |
C | CYS289 | |
D | GLY54 | |
D | TYR98 | |
D | ARG101 | |
D | GLN136 | |
D | CYS162 | |
D | CYS165 | |
A | GLN136 | |
D | CYS203 | |
D | CYS208 | |
D | GLY245 | |
D | ASN271 | |
D | CYS289 | |
A | CYS162 | |
A | CYS165 | |
A | CYS203 | |
A | CYS208 | |
A | GLY245 |