6ENW
X-ray structure of Auoxo4-encapsulated horse spleen apoferritin
Summary for 6ENW
| Entry DOI | 10.2210/pdb6enw/pdb |
| Descriptor | Ferritin light chain, CADMIUM ION, CHLORIDE ION, ... (6 entities in total) |
| Functional Keywords | drug delivery, nanocarrier, ferritin, gold, encapsulation, cytotoxicity, protein transport |
| Biological source | Equus caballus (Horse) |
| Total number of polymer chains | 1 |
| Total formula weight | 21610.11 |
| Authors | Ferraro, G.,Merlino, A. (deposition date: 2017-10-06, release date: 2017-12-13, Last modification date: 2024-01-17) |
| Primary citation | Monti, D.M.,Ferraro, G.,Petruk, G.,Maiore, L.,Pane, F.,Amoresano, A.,Cinellu, M.A.,Merlino, A. Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells. Dalton Trans, 46:15354-15362, 2017 Cited by PubMed Abstract: Two anticancer gold(iii) compounds, Au2phen and Auoxo4, were encapsulated within a ferritin nanocage. The gold-compound loaded proteins were characterized by UV-Vis spectroscopy, inductively coupled plasma mass spectrometry and circular dichroism. X-ray crystallography shows that the compounds degrade upon encapsulation and gold(i) ions bind Ft within the cage, close to the side chains of Cys126. The gold-encapsulated nanocarriers are cytotoxic to human cancer cells. Au(i)-loaded Ft, obtained upon the encapsulation of Au2phen within the cage, induces oxidative stress activation, which finally leads to apoptosis in MCF-7 cells. PubMed: 29072740DOI: 10.1039/c7dt02370g PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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