6EM2
Crystal structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with Fasudil
Summary for 6EM2
| Entry DOI | 10.2210/pdb6em2/pdb |
| Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total) |
| Functional Keywords | transferase, fasudil, complex |
| Biological source | Cricetulus griseus (Chinese hamster) |
| Total number of polymer chains | 1 |
| Total formula weight | 41603.29 |
| Authors | Mueller, J.M.,Heine, A.,Klebe, G. (deposition date: 2017-10-01, release date: 2018-10-10, Last modification date: 2024-11-20) |
| Primary citation | Mueller, J.M.,Kirschner, R.,Geyer, A.,Klebe, G. Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019 Cited by DOI: 10.1021/acsomega.8b02364PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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