6ELW

High resolution structure of selenocysteine containing human GPX4

Summary for 6ELW

Entry DOI	10.2210/pdb6elw/pdb
Descriptor	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, CHLORIDE ION (3 entities in total)
Functional Keywords	human gpx4, peroxidase, selenoprotein, thioredoxin-fold, anti-oxidatve defense system, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	21912.96
Authors	Kalms, J.,Borchert, A.,Kuhn, H.,Scheerer, P. (deposition date: 2017-09-29, release date: 2018-06-20, Last modification date: 2024-01-17)
Primary citation	Borchert, A.,Kalms, J.,Roth, S.R.,Rademacher, M.,Schmidt, A.,Holzhutter, H.G.,Kuhn, H.,Scheerer, P. Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction. Biochim. Biophys. Acta, 1863:1095-1107, 2018 Cited by PubMed: 29883798 DOI: 10.1016/j.bbalip.2018.06.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation