6ELW

High resolution structure of selenocysteine containing human GPX4

6ELW の概要

• エントリーDOI: 10.2210/pdb6elw/pdb
• 分子名称: Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, CHLORIDE ION (3 entities in total)
• 機能のキーワード: human gpx4, peroxidase, selenoprotein, thioredoxin-fold, anti-oxidatve defense system, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21912.96

構造登録者

Kalms, J.,Borchert, A.,Kuhn, H.,Scheerer, P. (登録日: 2017-09-29, 公開日: 2018-06-20, 最終更新日: 2024-01-17)

• 主引用文献: Borchert, A.,Kalms, J.,Roth, S.R.,Rademacher, M.,Schmidt, A.,Holzhutter, H.G.,Kuhn, H.,Scheerer, P.; Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction.; Biochim. Biophys. Acta, 1863:1095-1107, 2018; PubMed: 29883798; DOI: 10.1016/j.bbalip.2018.06.006

実験手法

X-RAY DIFFRACTION (1.3 Å)