6EJX

The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function

6EJX の概要

• エントリーDOI: 10.2210/pdb6ejx/pdb
• 分子名称: Platelet glycoprotein Ib alpha chain, IMIDAZOLE, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• 機能のキーワード: gp1balpha, mac-1, blood clotting
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63550.65

構造登録者

Emsley, J.,Saleem, M. (登録日: 2017-09-24, 公開日: 2018-10-24, 最終更新日: 2024-01-17)

• 主引用文献: Morgan, J.,Saleem, M.,Ng, R.,Armstrong, C.,Wong, S.S.,Caulton, S.G.,Fickling, A.,Williams, H.E.L.,Munday, A.D.,Lopez, J.A.,Searle, M.S.,Emsley, J.; Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib.; Blood Adv, 3:1450-1459, 2019; PubMed: 31053572; DOI: 10.1182/bloodadvances.2018027011

実験手法

X-RAY DIFFRACTION (2 Å)