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6EJ3

BACE1 compound 23

Summary for 6EJ3
Entry DOI10.2210/pdb6ej3/pdb
Related6EJ2
DescriptorBeta-secretase 1, (1r,4r)-4-methoxy-6'-(5-methyl-3-pyridinyl)-3'H-dispiro[cyclohexane-1,2'-indene-1',4''-[1,3]oxazol]-2''-amine (3 entities in total)
Functional Keywordsbace1, protease, alzheimer, peptide binding protein
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein: P56817
Total number of polymer chains1
Total formula weight56192.97
Authors
Johansson, P. (deposition date: 2017-09-20, release date: 2018-04-18, Last modification date: 2018-05-09)
Primary citationJohansson, P.,Kaspersson, K.,Gurrell, I.K.,Back, E.,Eketjall, S.,Scott, C.W.,Cebers, G.,Thorne, P.,McKenzie, M.J.,Beaton, H.,Davey, P.,Kolmodin, K.,Holenz, J.,Duggan, M.E.,Budd Haeberlein, S.,Burli, R.W.
Toward beta-Secretase-1 Inhibitors with Improved Isoform Selectivity.
J. Med. Chem., 61:3491-3502, 2018
Cited by
PubMed: 29617572
DOI: 10.1021/acs.jmedchem.7b01716
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.94 Å)
Structure validation

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