6EJ3

BACE1 compound 23

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue B7T A 501

Chain	Residue
A	GLY11
A	GLY230
A	GLY13
A	ASP32
A	ASN37
A	VAL69
A	TRP76
A	ILE110
A	ILE118
A	ASP228

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV

Chain	Residue	Details
A	ILE29-VAL40

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	435
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	THR-39-THR396

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site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE397-CYS417

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site_id	SWS_FT_FI3
Number of Residues	22
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	GLN418-LYS440

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site_id	SWS_FT_FI4
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094

Chain	Residue	Details
A	ASP32
A	ASP228

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site_id	SWS_FT_FI5
Number of Residues	7
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17425515, ECO:0000269|PubMed:19011241

Chain	Residue	Details
A	LYS65
A	LYS214
A	LYS218
A	LYS224
A	LYS238
A	LYS239
A	LYS246

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:15886016

Chain	Residue	Details
A	SER437

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site_id	SWS_FT_FI7
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P56818

Chain	Residue	Details
A	CYS413
A	CYS417
A	CYS421
A	CYS424

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site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN92
A	ASN111
A	ASN162
A	ASN293

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site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:27302062

Chain	Residue	Details
A	LYS440

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