6EHO

Dimer of the Sortilin Vps10p domain at low pH

Summary for 6EHO

• Entry DOI: 10.2210/pdb6eho/pdb
• Descriptor: Sortilin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: protein sorting receptor, 10-bladed beta-propeller, vps10p-d, endocytosis, endosome, glycoprotein, golgi apparatus, lysosome, membrane, receptor, transmembrane, signaling protein, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 82302.56

Authors

Thirup, S.S.,Quistgaard, E.H.,Januliene, D.,Andersen, J.L.,Nielsen, J.A. (deposition date: 2017-09-14, release date: 2017-12-06, Last modification date: 2024-01-17)

• Primary citation: Januliene, D.,Andersen, J.L.,Nielsen, J.A.,Quistgaard, E.M.,Hansen, M.,Strandbygaard, D.,Moeller, A.,Petersen, C.M.,Madsen, P.,Thirup, S.S.; Acidic Environment Induces Dimerization and Ligand Binding Site Collapse in the Vps10p Domain of Sortilin.; Structure, 25:1809-1819.e3, 2017; PubMed: 29107483; DOI: 10.1016/j.str.2017.09.015

Experimental method

X-RAY DIFFRACTION (3.5 Å)