6EHO

Dimer of the Sortilin Vps10p domain at low pH

6EHO の概要

• エントリーDOI: 10.2210/pdb6eho/pdb
• 分子名称: Sortilin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: protein sorting receptor, 10-bladed beta-propeller, vps10p-d, endocytosis, endosome, glycoprotein, golgi apparatus, lysosome, membrane, receptor, transmembrane, signaling protein, protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 82302.56

構造登録者

Thirup, S.S.,Quistgaard, E.H.,Januliene, D.,Andersen, J.L.,Nielsen, J.A. (登録日: 2017-09-14, 公開日: 2017-12-06, 最終更新日: 2024-01-17)

• 主引用文献: Januliene, D.,Andersen, J.L.,Nielsen, J.A.,Quistgaard, E.M.,Hansen, M.,Strandbygaard, D.,Moeller, A.,Petersen, C.M.,Madsen, P.,Thirup, S.S.; Acidic Environment Induces Dimerization and Ligand Binding Site Collapse in the Vps10p Domain of Sortilin.; Structure, 25:1809-1819.e3, 2017; PubMed: 29107483; DOI: 10.1016/j.str.2017.09.015

実験手法

X-RAY DIFFRACTION (3.5 Å)