6EHH
Crystal structure of mouse MTH1 mutant L116M with inhibitor TH588
Summary for 6EHH
Entry DOI | 10.2210/pdb6ehh/pdb |
Related | 5MZE 5MZF 5MZG |
Descriptor | 7,8-dihydro-8-oxoguanine triphosphatase, N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine, NITRATE ION, ... (8 entities in total) |
Functional Keywords | inhibitor, mutant, mth1, mouse, hydrolase |
Biological source | Mus musculus (House Mouse) |
Cellular location | Cytoplasm: P53368 |
Total number of polymer chains | 4 |
Total formula weight | 84015.02 |
Authors | Gustafsson, R.,Narwal, M.,Jemth, A.-S.,Almlof, I.,Warpman Berglund, U.,Helleday, T.,Stenmark, P. (deposition date: 2017-09-13, release date: 2018-01-10, Last modification date: 2024-01-17) |
Primary citation | Narwal, M.,Jemth, A.S.,Gustafsson, R.,Almlof, I.,Warpman Berglund, U.,Helleday, T.,Stenmark, P. Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity. Biochemistry, 57:593-603, 2018 Cited by PubMed: 29281266DOI: 10.1021/acs.biochem.7b01163 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report