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6EHH

Crystal structure of mouse MTH1 mutant L116M with inhibitor TH588

Summary for 6EHH
Entry DOI10.2210/pdb6ehh/pdb
Related5MZE 5MZF 5MZG
Descriptor7,8-dihydro-8-oxoguanine triphosphatase, N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine, NITRATE ION, ... (8 entities in total)
Functional Keywordsinhibitor, mutant, mth1, mouse, hydrolase
Biological sourceMus musculus (House Mouse)
Cellular locationCytoplasm: P53368
Total number of polymer chains4
Total formula weight84015.02
Authors
Gustafsson, R.,Narwal, M.,Jemth, A.-S.,Almlof, I.,Warpman Berglund, U.,Helleday, T.,Stenmark, P. (deposition date: 2017-09-13, release date: 2018-01-10, Last modification date: 2024-01-17)
Primary citationNarwal, M.,Jemth, A.S.,Gustafsson, R.,Almlof, I.,Warpman Berglund, U.,Helleday, T.,Stenmark, P.
Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Biochemistry, 57:593-603, 2018
Cited by
PubMed: 29281266
DOI: 10.1021/acs.biochem.7b01163
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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