6EEE

X-ray crystal structure of Pf-M17 in complex with inhibitor (6k) and regulatory zinc ion

Summary for 6EEE

Entry DOI	10.2210/pdb6eee/pdb
Descriptor	M17 LEUCYL-AMINOPEPTIDASE, (1R,2r,3S,5R,7R)-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]tricyclo[3.3.1.1~3,7~]decane-2-carboxamide, CARBONATE ION, ... (10 entities in total)
Functional Keywords	m17 leucyl-aminopeptidase, protease, inhibitor, hydroxamic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum (isolate HB3)
Total number of polymer chains	12
Total formula weight	707993.05
Authors	Drinkwater, N.,McGowan, S. (deposition date: 2018-08-13, release date: 2018-12-26, Last modification date: 2024-03-13)
Primary citation	Vinh, N.B.,Drinkwater, N.,Malcolm, T.R.,Kassiou, M.,Lucantoni, L.,Grin, P.M.,Butler, G.S.,Duffy, S.,Overall, C.M.,Avery, V.M.,Scammells, P.J.,McGowan, S. Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. J. Med. Chem., 62:622-640, 2019 Cited by PubMed: 30537832 DOI: 10.1021/acs.jmedchem.8b01310 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation