6EE2

X-ray crystal structure of Pf-M17 in complex with inhibitor 6i and regulatory zinc ion

Summary for 6EE2

• Entry DOI: 10.2210/pdb6ee2/pdb
• Descriptor: Pf-M17, CARBONATE ION, ZINC ION, ... (9 entities in total)
• Functional Keywords: m17 leucyl-aminopeptidase, protease, inhibitor, hydroxamic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Plasmodium falciparum NF135/5.C10
• Total number of polymer chains: 12
• Total formula weight: 719510.41

Authors

Drinkwater, N.,McGowan, S. (deposition date: 2018-08-13, release date: 2018-12-26, Last modification date: 2024-03-13)

• Primary citation: Vinh, N.B.,Drinkwater, N.,Malcolm, T.R.,Kassiou, M.,Lucantoni, L.,Grin, P.M.,Butler, G.S.,Duffy, S.,Overall, C.M.,Avery, V.M.,Scammells, P.J.,McGowan, S.; Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.; J. Med. Chem., 62:622-640, 2019; PubMed: 30537832; DOI: 10.1021/acs.jmedchem.8b01310

Experimental method

X-RAY DIFFRACTION (2.1 Å)