6EE2
X-ray crystal structure of Pf-M17 in complex with inhibitor 6i and regulatory zinc ion
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0019538 | biological_process | protein metabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0019538 | biological_process | protein metabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0019538 | biological_process | protein metabolic process |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070006 | molecular_function | metalloaminopeptidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006508 | biological_process | proteolysis |
| D | 0019538 | biological_process | protein metabolic process |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070006 | molecular_function | metalloaminopeptidase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006508 | biological_process | proteolysis |
| E | 0019538 | biological_process | protein metabolic process |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070006 | molecular_function | metalloaminopeptidase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006508 | biological_process | proteolysis |
| F | 0019538 | biological_process | protein metabolic process |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070006 | molecular_function | metalloaminopeptidase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006508 | biological_process | proteolysis |
| G | 0019538 | biological_process | protein metabolic process |
| G | 0030145 | molecular_function | manganese ion binding |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0070006 | molecular_function | metalloaminopeptidase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006508 | biological_process | proteolysis |
| H | 0019538 | biological_process | protein metabolic process |
| H | 0030145 | molecular_function | manganese ion binding |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0070006 | molecular_function | metalloaminopeptidase activity |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006508 | biological_process | proteolysis |
| I | 0019538 | biological_process | protein metabolic process |
| I | 0030145 | molecular_function | manganese ion binding |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0070006 | molecular_function | metalloaminopeptidase activity |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006508 | biological_process | proteolysis |
| J | 0019538 | biological_process | protein metabolic process |
| J | 0030145 | molecular_function | manganese ion binding |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0070006 | molecular_function | metalloaminopeptidase activity |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0006508 | biological_process | proteolysis |
| K | 0019538 | biological_process | protein metabolic process |
| K | 0030145 | molecular_function | manganese ion binding |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0070006 | molecular_function | metalloaminopeptidase activity |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006508 | biological_process | proteolysis |
| L | 0019538 | biological_process | protein metabolic process |
| L | 0030145 | molecular_function | manganese ion binding |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 A 701 |
| Chain | Residue |
| A | LYS374 |
| A | ALA460 |
| A | GLY462 |
| A | ARG463 |
| A | LEU487 |
| A | J1V703 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 702 |
| Chain | Residue |
| A | J1V703 |
| A | ASP379 |
| A | ASP459 |
| A | GLU461 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue J1V A 703 |
| Chain | Residue |
| A | LYS374 |
| A | ASP379 |
| A | LYS386 |
| A | GLY390 |
| A | MET392 |
| A | ASP399 |
| A | ASP459 |
| A | ALA460 |
| A | GLU461 |
| A | LEU487 |
| A | THR488 |
| A | GLY489 |
| A | LEU492 |
| A | ALA577 |
| A | PHE583 |
| A | CO3701 |
| A | ZN702 |
| A | HOH812 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 704 |
| Chain | Residue |
| A | GLU102 |
| A | TYR103 |
| A | ASN104 |
| A | 1PE707 |
| A | HOH905 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 705 |
| Chain | Residue |
| A | LYS111 |
| A | HOH811 |
| G | GLU125 |
| G | GLY126 |
| G | SER220 |
| J | LYS164 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE A 706 |
| Chain | Residue |
| A | TYR103 |
| A | ASN104 |
| A | LEU321 |
| A | TYR411 |
| A | HOH1000 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE A 707 |
| Chain | Residue |
| A | GLU316 |
| A | LYS320 |
| A | SO4704 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 708 |
| Chain | Residue |
| A | SER435 |
| A | LYS436 |
| B | SER435 |
| B | LYS436 |
| B | HOH975 |
| C | SER435 |
| C | LYS436 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 709 |
| Chain | Residue |
| A | LEU214 |
| A | HIS215 |
| A | ASP216 |
| A | ASN217 |
| A | TYR246 |
| A | GLU262 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 710 |
| Chain | Residue |
| A | GLY126 |
| A | LEU219 |
| A | SER220 |
| A | HOH806 |
| G | LYS111 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 711 |
| Chain | Residue |
| A | LEU492 |
| A | PHE583 |
| F | LYS552 |
| F | HOH969 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 712 |
| Chain | Residue |
| A | ARG586 |
| A | HOH885 |
| C | ASN545 |
| C | SER549 |
| C | HOH911 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 B 701 |
| Chain | Residue |
| B | LYS374 |
| B | ALA460 |
| B | GLY462 |
| B | ARG463 |
| B | LEU487 |
| B | J1V703 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 702 |
| Chain | Residue |
| B | ASP379 |
| B | ASP459 |
| B | GLU461 |
| B | J1V703 |
| site_id | AD6 |
| Number of Residues | 20 |
| Details | binding site for residue J1V B 703 |
| Chain | Residue |
| B | CO3701 |
| B | ZN702 |
| B | HOH823 |
| B | HOH876 |
| B | HOH939 |
| B | LYS374 |
| B | ASP379 |
| B | LYS386 |
| B | GLY390 |
| B | MET392 |
| B | ASP399 |
| B | ASN457 |
| B | ASP459 |
| B | GLU461 |
| B | LEU487 |
| B | THR488 |
| B | GLY489 |
| B | LEU492 |
| B | ALA577 |
| B | PHE583 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE B 704 |
| Chain | Residue |
| B | TYR103 |
| B | HIS108 |
| B | LYS320 |
| B | TYR411 |
| B | 1PE705 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE B 705 |
| Chain | Residue |
| B | TYR103 |
| B | GLU316 |
| B | LYS320 |
| B | 1PE704 |
| H | 1PE704 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 706 |
| Chain | Residue |
| B | ASN506 |
| B | ASN568 |
| B | THR569 |
| B | ALA570 |
| B | HOH1015 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 707 |
| Chain | Residue |
| B | PHE156 |
| B | ASN161 |
| B | LYS164 |
| F | TYR176 |
| F | PHE178 |
| F | SER184 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 C 701 |
| Chain | Residue |
| C | LYS374 |
| C | ALA460 |
| C | GLY462 |
| C | ARG463 |
| C | LEU487 |
| C | J1V703 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 702 |
| Chain | Residue |
| C | ASP379 |
| C | ASP459 |
| C | GLU461 |
| C | J1V703 |
| site_id | AE4 |
| Number of Residues | 18 |
| Details | binding site for residue J1V C 703 |
| Chain | Residue |
| C | LYS374 |
| C | ASP379 |
| C | LYS386 |
| C | GLY390 |
| C | MET392 |
| C | ASP399 |
| C | ASN457 |
| C | ASP459 |
| C | GLU461 |
| C | LEU487 |
| C | THR488 |
| C | GLY489 |
| C | LEU492 |
| C | ALA577 |
| C | PHE583 |
| C | CO3701 |
| C | ZN702 |
| C | HOH853 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE C 704 |
| Chain | Residue |
| C | TYR103 |
| C | GLU316 |
| C | LYS320 |
| C | 1PE705 |
| C | HOH973 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE C 705 |
| Chain | Residue |
| C | TYR103 |
| C | ASN104 |
| C | HIS108 |
| C | TYR411 |
| C | 1PE704 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue DMS C 706 |
| Chain | Residue |
| C | LEU214 |
| C | HIS215 |
| C | ASP216 |
| C | ASN217 |
| C | TYR246 |
| C | MET261 |
| C | GLU262 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 707 |
| Chain | Residue |
| C | PHE156 |
| C | ASN161 |
| C | LYS164 |
| E | TYR176 |
| E | SER184 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 D 701 |
| Chain | Residue |
| D | LYS374 |
| D | ALA460 |
| D | GLY462 |
| D | ARG463 |
| D | LEU487 |
| D | J1V703 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 702 |
| Chain | Residue |
| D | ASP379 |
| D | ASP459 |
| D | GLU461 |
| D | J1V703 |
| site_id | AF2 |
| Number of Residues | 17 |
| Details | binding site for residue J1V D 703 |
| Chain | Residue |
| D | LYS374 |
| D | ASP379 |
| D | LYS386 |
| D | GLY390 |
| D | MET392 |
| D | ASP399 |
| D | ASP459 |
| D | GLU461 |
| D | LEU487 |
| D | THR488 |
| D | GLY489 |
| D | LEU492 |
| D | ALA577 |
| D | PHE583 |
| D | CO3701 |
| D | ZN702 |
| D | HOH889 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 704 |
| Chain | Residue |
| D | TYR103 |
| D | ASN104 |
| D | 1PE708 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 705 |
| Chain | Residue |
| D | SER435 |
| D | LYS436 |
| E | SER435 |
| E | LYS436 |
| F | SER435 |
| F | LYS436 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE D 706 |
| Chain | Residue |
| D | TYR103 |
| D | ASN104 |
| D | HIS108 |
| D | TYR411 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE D 707 |
| Chain | Residue |
| D | ASN449 |
| D | LYS451 |
| D | ASP543 |
| D | GLN567 |
| E | SER254 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE D 708 |
| Chain | Residue |
| D | TYR103 |
| D | GLU316 |
| D | LYS320 |
| D | SO4704 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE D 709 |
| Chain | Residue |
| D | ASN505 |
| D | ASN506 |
| D | THR569 |
| D | ALA570 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue DMS D 710 |
| Chain | Residue |
| D | SER86 |
| D | GLU87 |
| D | VAL88 |
| D | THR97 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 E 701 |
| Chain | Residue |
| E | LYS374 |
| E | ALA460 |
| E | GLY462 |
| E | ARG463 |
| E | LEU487 |
| E | J1V703 |
| site_id | AG2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 702 |
| Chain | Residue |
| E | ASP379 |
| E | ASP459 |
| E | GLU461 |
| E | J1V703 |
| site_id | AG3 |
| Number of Residues | 20 |
| Details | binding site for residue J1V E 703 |
| Chain | Residue |
| E | LYS374 |
| E | ASP379 |
| E | LYS386 |
| E | GLY390 |
| E | MET392 |
| E | ASP399 |
| E | ASN457 |
| E | ASP459 |
| E | GLU461 |
| E | LEU487 |
| E | THR488 |
| E | GLY489 |
| E | LEU492 |
| E | ALA577 |
| E | PHE583 |
| E | CO3701 |
| E | ZN702 |
| E | HOH823 |
| E | HOH873 |
| E | HOH904 |
| site_id | AG4 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE E 704 |
| Chain | Residue |
| E | TYR103 |
| E | GLU316 |
| E | LYS320 |
| site_id | AG5 |
| Number of Residues | 7 |
| Details | binding site for residue 1PE E 705 |
| Chain | Residue |
| E | TYR103 |
| E | ASN104 |
| E | PHE289 |
| E | LYS320 |
| E | TYR411 |
| E | HOH837 |
| E | HOH907 |
| site_id | AG6 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE E 706 |
| Chain | Residue |
| E | ASN449 |
| E | LYS451 |
| E | ASP543 |
| E | GLU564 |
| F | SER254 |
| site_id | AG7 |
| Number of Residues | 5 |
| Details | binding site for residue DMS E 707 |
| Chain | Residue |
| E | ASN505 |
| E | ASN506 |
| E | ASN568 |
| E | THR569 |
| E | ALA570 |
| site_id | AG8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 E 708 |
| Chain | Residue |
| E | SER86 |
| E | GLU87 |
| E | VAL88 |
| E | THR97 |
| E | ASN312 |
| E | HOH885 |
| site_id | AG9 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 E 709 |
| Chain | Residue |
| E | GLU324 |
| E | TYR325 |
| site_id | AH1 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 F 701 |
| Chain | Residue |
| F | LYS374 |
| F | ALA460 |
| F | GLY462 |
| F | ARG463 |
| F | LEU487 |
| F | J1V703 |
| site_id | AH2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 702 |
| Chain | Residue |
| F | ASP379 |
| F | ASP459 |
| F | GLU461 |
| F | J1V703 |
| site_id | AH3 |
| Number of Residues | 19 |
| Details | binding site for residue J1V F 703 |
| Chain | Residue |
| F | LYS374 |
| F | ASP379 |
| F | LYS386 |
| F | GLY390 |
| F | MET392 |
| F | LEU395 |
| F | ASP399 |
| F | ASN457 |
| F | ASP459 |
| F | GLU461 |
| F | LEU487 |
| F | THR488 |
| F | GLY489 |
| F | LEU492 |
| F | ALA577 |
| F | PHE583 |
| F | CO3701 |
| F | ZN702 |
| F | HOH839 |
| site_id | AH4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 F 704 |
| Chain | Residue |
| F | GLU102 |
| F | TYR103 |
| F | ASN104 |
| F | 1PE706 |
| site_id | AH5 |
| Number of Residues | 7 |
| Details | binding site for residue 1PE F 705 |
| Chain | Residue |
| F | TYR103 |
| F | ASN104 |
| F | HIS108 |
| F | PHE289 |
| F | LYS320 |
| F | TYR411 |
| F | HOH863 |
| site_id | AH6 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE F 706 |
| Chain | Residue |
| F | TYR103 |
| F | ASN104 |
| F | GLU316 |
| F | LYS320 |
| F | SO4704 |
| F | HOH982 |
| site_id | AH7 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE F 707 |
| Chain | Residue |
| D | SER254 |
| F | ASN449 |
| F | LYS451 |
| F | ASP543 |
| F | GLN567 |
| F | HOH818 |
| site_id | AH8 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 G 701 |
| Chain | Residue |
| G | LYS374 |
| G | ALA460 |
| G | GLY462 |
| G | ARG463 |
| G | LEU487 |
| G | J1V703 |
| site_id | AH9 |
| Number of Residues | 5 |
| Details | binding site for residue ZN G 702 |
| Chain | Residue |
| G | ASP379 |
| G | LYS386 |
| G | ASP459 |
| G | GLU461 |
| G | J1V703 |
| site_id | AI1 |
| Number of Residues | 19 |
| Details | binding site for residue J1V G 703 |
| Chain | Residue |
| G | LYS374 |
| G | ASP379 |
| G | LYS386 |
| G | GLY390 |
| G | MET392 |
| G | LEU395 |
| G | ASP399 |
| G | ASP459 |
| G | GLU461 |
| G | LEU487 |
| G | THR488 |
| G | GLY489 |
| G | LEU492 |
| G | ALA577 |
| G | PHE583 |
| G | CO3701 |
| G | ZN702 |
| G | HOH840 |
| L | SO4710 |
| site_id | AI2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 G 704 |
| Chain | Residue |
| G | SER435 |
| G | LYS436 |
| G | HOH830 |
| H | SER435 |
| H | LYS436 |
| I | SER435 |
| I | LYS436 |
| site_id | AI3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 G 705 |
| Chain | Residue |
| G | GLU102 |
| G | TYR103 |
| G | ASN104 |
| G | 1PE709 |
| G | HOH1026 |
| site_id | AI4 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE G 706 |
| Chain | Residue |
| G | TYR103 |
| G | ASN104 |
| G | HIS108 |
| G | TYR411 |
| site_id | AI5 |
| Number of Residues | 9 |
| Details | binding site for residue 1PE G 707 |
| Chain | Residue |
| A | TYR115 |
| A | ASN122 |
| A | GLU124 |
| A | TYR270 |
| G | TYR115 |
| G | ASN122 |
| G | GLU124 |
| G | TYR270 |
| G | 1PE708 |
| site_id | AI6 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE G 708 |
| Chain | Residue |
| A | ASN122 |
| G | ASN122 |
| G | 1PE707 |
| site_id | AI7 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE G 709 |
| Chain | Residue |
| E | GLU124 |
| G | TYR103 |
| G | ASN104 |
| G | GLU316 |
| G | LYS320 |
| G | SO4705 |
| site_id | AI8 |
| Number of Residues | 7 |
| Details | binding site for residue DMS G 710 |
| Chain | Residue |
| G | TYR244 |
| G | ASP249 |
| G | TYR292 |
| G | SER295 |
| G | LYS587 |
| G | HOH997 |
| I | TYR541 |
| site_id | AI9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 G 711 |
| Chain | Residue |
| G | ASN545 |
| G | SER549 |
| G | HOH849 |
| G | HOH910 |
| G | HOH949 |
| H | ARG586 |
| site_id | AJ1 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 H 701 |
| Chain | Residue |
| H | LYS374 |
| H | ALA460 |
| H | GLY462 |
| H | ARG463 |
| H | LEU487 |
| H | J1V703 |
| site_id | AJ2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN H 702 |
| Chain | Residue |
| H | ASP379 |
| H | ASP459 |
| H | GLU461 |
| H | J1V703 |
| site_id | AJ3 |
| Number of Residues | 19 |
| Details | binding site for residue J1V H 703 |
| Chain | Residue |
| H | LYS374 |
| H | ASP379 |
| H | LYS386 |
| H | GLY390 |
| H | MET392 |
| H | ASP399 |
| H | ASN457 |
| H | ASP459 |
| H | GLU461 |
| H | LEU487 |
| H | THR488 |
| H | GLY489 |
| H | LEU492 |
| H | ALA577 |
| H | PHE583 |
| H | CO3701 |
| H | ZN702 |
| H | HOH805 |
| H | HOH982 |
| site_id | AJ4 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE H 704 |
| Chain | Residue |
| B | 1PE705 |
| H | TYR103 |
| H | HIS108 |
| H | LYS320 |
| H | LEU321 |
| H | TYR411 |
| site_id | AJ5 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE H 705 |
| Chain | Residue |
| H | TYR103 |
| H | GLU316 |
| H | LYS320 |
| site_id | AJ6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN I 701 |
| Chain | Residue |
| I | ASP379 |
| I | ASP459 |
| I | GLU461 |
| I | J1V703 |
| site_id | AJ7 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 I 702 |
| Chain | Residue |
| I | LYS374 |
| I | ALA460 |
| I | GLY462 |
| I | ARG463 |
| I | LEU487 |
| I | J1V703 |
| site_id | AJ8 |
| Number of Residues | 17 |
| Details | binding site for residue J1V I 703 |
| Chain | Residue |
| I | LYS374 |
| I | ASP379 |
| I | LYS386 |
| I | GLY390 |
| I | MET392 |
| I | ASP399 |
| I | ASP459 |
| I | GLU461 |
| I | LEU487 |
| I | THR488 |
| I | GLY489 |
| I | ALA577 |
| I | PHE583 |
| I | ZN701 |
| I | CO3702 |
| I | HOH832 |
| I | HOH1029 |
| site_id | AJ9 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE I 704 |
| Chain | Residue |
| I | TYR103 |
| I | GLU316 |
| I | LYS320 |
| I | 1PE705 |
| I | SO4710 |
| site_id | AK1 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE I 705 |
| Chain | Residue |
| I | TYR103 |
| I | ASN104 |
| I | HIS108 |
| I | PHE289 |
| I | TYR411 |
| I | 1PE704 |
| site_id | AK2 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE I 706 |
| Chain | Residue |
| I | TYR115 |
| I | GLY119 |
| I | GLY120 |
| I | ASN122 |
| I | ASN149 |
| I | TYR270 |
| site_id | AK3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO I 707 |
| Chain | Residue |
| I | ASN506 |
| I | THR569 |
| I | ALA570 |
| I | HOH856 |
| site_id | AK4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO I 708 |
| Chain | Residue |
| I | GLY126 |
| I | LEU219 |
| I | SER220 |
| site_id | AK5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 I 709 |
| Chain | Residue |
| H | ASN545 |
| H | SER549 |
| H | HOH892 |
| H | HOH895 |
| I | ARG586 |
| site_id | AK6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 I 710 |
| Chain | Residue |
| I | ILE101 |
| I | GLU102 |
| I | TYR103 |
| I | ASN104 |
| I | 1PE704 |
| site_id | AK7 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 J 701 |
| Chain | Residue |
| J | LYS374 |
| J | ALA460 |
| J | GLY462 |
| J | ARG463 |
| J | LEU487 |
| J | J1V703 |
| site_id | AK8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN J 702 |
| Chain | Residue |
| J | ASP379 |
| J | ASP459 |
| J | GLU461 |
| J | J1V703 |
| site_id | AK9 |
| Number of Residues | 18 |
| Details | binding site for residue J1V J 703 |
| Chain | Residue |
| J | LYS374 |
| J | ASP379 |
| J | LYS386 |
| J | GLY390 |
| J | MET392 |
| J | ASP399 |
| J | ASP459 |
| J | GLU461 |
| J | LEU487 |
| J | THR488 |
| J | GLY489 |
| J | LEU492 |
| J | ALA577 |
| J | PHE583 |
| J | CO3701 |
| J | ZN702 |
| J | HOH812 |
| J | HOH886 |
| site_id | AL1 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE J 704 |
| Chain | Residue |
| J | ASP95 |
| J | PRO96 |
| J | THR97 |
| site_id | AL2 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE J 705 |
| Chain | Residue |
| J | TYR103 |
| J | HIS108 |
| J | TYR411 |
| site_id | AL3 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE J 706 |
| Chain | Residue |
| J | TYR103 |
| J | GLU316 |
| J | LYS320 |
| site_id | AL4 |
| Number of Residues | 6 |
| Details | binding site for residue DMS J 707 |
| Chain | Residue |
| G | PHE156 |
| G | ASN161 |
| G | LYS164 |
| G | PHE165 |
| J | MET177 |
| J | SER184 |
| site_id | AL5 |
| Number of Residues | 6 |
| Details | binding site for residue CO3 K 701 |
| Chain | Residue |
| K | LYS374 |
| K | ALA460 |
| K | GLY462 |
| K | ARG463 |
| K | LEU487 |
| K | J1V703 |
| site_id | AL6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN K 702 |
| Chain | Residue |
| K | ASP379 |
| K | ASP459 |
| K | GLU461 |
| K | J1V703 |
| site_id | AL7 |
| Number of Residues | 18 |
| Details | binding site for residue J1V K 703 |
| Chain | Residue |
| K | LYS374 |
| K | ASP379 |
| K | LYS386 |
| K | GLY390 |
| K | MET392 |
| K | ASP399 |
| K | ASN457 |
| K | ASP459 |
| K | GLU461 |
| K | LEU487 |
| K | THR488 |
| K | GLY489 |
| K | LEU492 |
| K | ALA577 |
| K | PHE583 |
| K | CO3701 |
| K | ZN702 |
| K | HOH856 |
| site_id | AL8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 K 704 |
| Chain | Residue |
| K | ILE101 |
| K | TYR103 |
| K | ASN104 |
| K | HOH1029 |
| site_id | AL9 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE K 705 |
| Chain | Residue |
| K | TYR103 |
| K | GLU316 |
| K | GLN319 |
| K | LYS320 |
| site_id | AM1 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE K 706 |
| Chain | Residue |
| K | TYR103 |
| K | ASN104 |
| K | HIS108 |
| K | LYS320 |
| K | TYR411 |
| K | HOH1021 |
| site_id | AM2 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE K 707 |
| Chain | Residue |
| K | ASN449 |
| K | LYS451 |
| K | ASP543 |
| K | GLU564 |
| K | GLN567 |
| L | SER254 |
| site_id | AM3 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE K 708 |
| Chain | Residue |
| K | ASP95 |
| K | PRO96 |
| K | HOH1130 |
| site_id | AM4 |
| Number of Residues | 8 |
| Details | binding site for residue DMS K 709 |
| Chain | Residue |
| K | ASN545 |
| K | SER549 |
| K | HOH832 |
| K | HOH865 |
| K | HOH943 |
| L | ARG586 |
| L | HOH1078 |
| L | HOH1096 |
| site_id | AM5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 K 710 |
| Chain | Residue |
| I | PHE156 |
| I | ASN161 |
| I | LYS164 |
| I | PHE165 |
| K | TYR176 |
| K | MET177 |
| K | SER184 |
| site_id | AM6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 K 711 |
| Chain | Residue |
| J | SER435 |
| J | LYS436 |
| K | SER435 |
| K | LYS436 |
| L | SER435 |
| L | LYS436 |
| site_id | AM7 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE L 701 |
| Chain | Residue |
| G | TRP526 |
| G | HOH990 |
| L | ASN511 |
| L | TRP526 |
| L | HOH1004 |
| site_id | AM8 |
| Number of Residues | 7 |
| Details | binding site for residue CO3 L 702 |
| Chain | Residue |
| L | LYS374 |
| L | ALA460 |
| L | GLU461 |
| L | GLY462 |
| L | ARG463 |
| L | LEU487 |
| L | J1V704 |
| site_id | AM9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN L 703 |
| Chain | Residue |
| L | ASP379 |
| L | ASP459 |
| L | GLU461 |
| L | J1V704 |
| site_id | AN1 |
| Number of Residues | 20 |
| Details | binding site for residue J1V L 704 |
| Chain | Residue |
| L | LYS374 |
| L | ASP379 |
| L | LYS386 |
| L | GLY390 |
| L | MET392 |
| L | LEU395 |
| L | ASP399 |
| L | ASN457 |
| L | ASP459 |
| L | GLU461 |
| L | LEU487 |
| L | THR488 |
| L | GLY489 |
| L | LEU492 |
| L | ALA577 |
| L | PHE583 |
| L | CO3702 |
| L | ZN703 |
| L | HOH807 |
| L | HOH812 |
| site_id | AN2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 L 705 |
| Chain | Residue |
| L | ILE101 |
| L | GLU102 |
| L | TYR103 |
| L | ASN104 |
| L | 1PE708 |
| site_id | AN3 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE L 706 |
| Chain | Residue |
| L | TYR103 |
| L | ASN104 |
| L | LYS320 |
| L | TYR411 |
| L | HOH876 |
| site_id | AN4 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE L 707 |
| Chain | Residue |
| J | SER254 |
| L | ASN449 |
| L | LYS451 |
| L | ASP543 |
| L | GLN567 |
| L | HOH803 |
| site_id | AN5 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE L 708 |
| Chain | Residue |
| L | TYR103 |
| L | GLU316 |
| L | LYS320 |
| L | SO4705 |
| site_id | AN6 |
| Number of Residues | 10 |
| Details | binding site for residue 1PE L 709 |
| Chain | Residue |
| J | ALA387 |
| J | HOH904 |
| L | ASN384 |
| L | LEU385 |
| L | ALA387 |
| L | ALA388 |
| L | SER391 |
| L | ASN457 |
| L | HOH813 |
| L | HOH879 |
| site_id | AN7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 L 710 |
| Chain | Residue |
| G | PHE583 |
| G | J1V703 |
| L | LYS552 |
| L | HOH901 |
| site_id | AN8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 L 711 |
| Chain | Residue |
| G | TYR499 |
| L | ILE529 |
| L | ILE530 |
| L | ASN531 |
| L | HOH995 |
Functional Information from PROSITE/UniProt
| site_id | PS00631 |
| Number of Residues | 8 |
| Details | CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL |
| Chain | Residue | Details |
| A | ASN457-LEU464 |
