6ECQ
The human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (FolD) complexed with NADP and inhibitor LY345899
Summary for 6ECQ
Entry DOI | 10.2210/pdb6ecq/pdb |
Descriptor | METHYLENETETRAHYDROFOLATE DEHYDROGENASE CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-{4-[(6aR)-3-amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzene-1-carbonyl}-L-glutamic acid, ... (4 entities in total) |
Functional Keywords | dehydrogenase, cyclohydrolase, bifunctional protein, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 66139.93 |
Authors | Bueno, R.V.,Dawson, A.,Hunter, W.N. (deposition date: 2018-08-08, release date: 2019-03-27, Last modification date: 2023-10-11) |
Primary citation | Bueno, R.,Dawson, A.,Hunter, W.N. An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase-ligand complexes following further refinement. Acta Crystallogr F Struct Biol Commun, 75:148-152, 2019 Cited by PubMed: 30839287DOI: 10.1107/S2053230X18018083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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