6ECQ
The human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (FolD) complexed with NADP and inhibitor LY345899
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | METHYLENETETRAHYDROFOLATE DEHYDROGENASE CYCLOHYDROLASE | polymer | 296 | 32090.8 | 2 | UniProt (P11586) Pfam (PF00763) Pfam (PF02882) | Homo sapiens (Human) | C1-THF synthase |
| 2 | C, E (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D (A) | N-{4-[(6aR)-3-amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzene-1-carbonyl}-L-glutamic acid | non-polymer | 471.4 | 1 | Chemie (LUD) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64181.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1958.2 | |
| All* | Total formula weight | 66139.9 |
