6ECK

Pyruvate Kinase Isoform L-type with phosphorylated Ser113 (pS113) in complex with FBP

Summary for 6ECK

• Entry DOI: 10.2210/pdb6eck/pdb
• Related: 6ECH
• Descriptor: Pyruvate kinase PKLR, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... (8 entities in total)
• Functional Keywords: pkl, pyruvate kinase, glycolysis, transferase
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 2
• Total formula weight: 121515.15

Authors

Padyana, A.,Tong, S. (deposition date: 2018-08-08, release date: 2019-12-04, Last modification date: 2023-10-11)

• Primary citation: Gassaway, B.M.,Cardone, R.L.,Padyana, A.K.,Petersen, M.C.,Judd, E.T.,Hayes, S.,Tong, S.,Barber, K.W.,Apostolidi, M.,Abulizi, A.,Sheetz, J.B.,Aerni, H.R.,Gross, S.,Kung, C.,Samuel, V.T.,Shulman, G.I.,Kibbey, R.G.,Rinehart, J.; Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.; Cell Rep, 29:3394-3404.e9, 2019; PubMed: 31825824; DOI: 10.1016/j.celrep.2019.11.009

Experimental method

X-RAY DIFFRACTION (2.36 Å)