6EAQ
Glycosylated FCGR3B / CD16b in complex with afucosylated IgG1 Fc
Summary for 6EAQ
Entry DOI | 10.2210/pdb6eaq/pdb |
Descriptor | Immunoglobulin gamma-1 heavy chain, Low affinity immunoglobulin gamma Fc region receptor III-B, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | glycosylation, glycoprotein, igg1 fc, cd16b, fcgr3b, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 73603.13 |
Authors | Roberts, J.T.,Barb, A.W. (deposition date: 2018-08-03, release date: 2018-11-07, Last modification date: 2023-10-11) |
Primary citation | Roberts, J.T.,Barb, A.W. A single amino acid distorts the Fc gamma receptor IIIb/CD16b structure upon binding immunoglobulin G1 and reduces affinity relative to CD16a. J. Biol. Chem., 293:19899-19908, 2018 Cited by PubMed: 30361439DOI: 10.1074/jbc.RA118.005273 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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