6EAQ

Glycosylated FCGR3B / CD16b in complex with afucosylated IgG1 Fc

6EAQ の概要

• エントリーDOI: 10.2210/pdb6eaq/pdb
• 分子名称: Immunoglobulin gamma-1 heavy chain, Low affinity immunoglobulin gamma Fc region receptor III-B, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: glycosylation, glycoprotein, igg1 fc, cd16b, fcgr3b, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 73603.13

構造登録者

Roberts, J.T.,Barb, A.W. (登録日: 2018-08-03, 公開日: 2018-11-07, 最終更新日: 2023-10-11)

• 主引用文献: Roberts, J.T.,Barb, A.W.; A single amino acid distorts the Fc gamma receptor IIIb/CD16b structure upon binding immunoglobulin G1 and reduces affinity relative to CD16a.; J. Biol. Chem., 293:19899-19908, 2018; PubMed: 30361439; DOI: 10.1074/jbc.RA118.005273

実験手法

X-RAY DIFFRACTION (2.22 Å)